EVOMELA J Code: J9246

Drug & Product Overview

HCPCS Descriptor Injection, melphalan (evomela), 1 mg

HCPCS Added Date July 1, 2020

Manufacturer Acrotech Biopharma

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About EVOMELA

Evomela is a medication aligned to the HCPCS J Code: J9246 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by Acrotech Biopharma.

According to CMS Drug Use Information: This medication is used to treat certain types of cancer (such as multiple myeloma, ovarian). Melphalan is also used as a pretreatment for people who are undergoing a stem cell transplant for multiple myeloma. Melphalan belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
72893-0001-01	Evomela	Acrotech Biopharma Inc	50	50 MG / 10 ML

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EVOMELA Pricing & Reimbursement

J9246 Private Payer Reimbursement

$19.15 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Melphalan 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J9246	Acrotech Biopharma	Melphalan	Injection, melphalan (evomela), 1 mg

EVOMELA CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Evomela (J9246) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

EVOMELA Medically Unlikely Edits (MUE)

The most billing units of J9246 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

EVOMELA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Multiple Myeloma

Drug Class

Alkylating Activity [MoA]Alkylating Drug [EPC]

Frequently Asked Questions

Is there an available Evomela billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for EVOMELA.

Are there any available Evomela patient assistance programs?

EVOMELA patient assistance information can be found through Acrotech Biopharma. Visit Here →

Where can I find Evomela prescribing information?

EVOMELA prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Evomela side effect information?

Our team has not yet identified a source of side effects information for EVOMELA. Please check back in a few weeks.

Does billing EVOMELA require JZ/JW wastage modifiers?

CMS has identified EVOMELA(J9246) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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