CYCLOPHOSPHAMIDE (AVYXA) J Code: J9072

Drug & Product Overview

HCPCS Descriptor Injection, cyclophosphamide (frindovyx), 5 mg

HCPCS Added Date January 1, 2024

Manufacturer Avyxa Pharma

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose, Multi-Dose

Dosage Form Injection

About CYCLOPHOSPHAMIDE (AVYXA)

Cyclophosphamide (avyxa) is a medication aligned to the HCPCS J Code: J9072 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by Avyxa Pharma.

According to CMS Drug Use Information: Cyclophosphamide is used to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system's response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 6 NDCs — log in for the full crosswalk.

NDC Code	Package	Manufacturer	HCPCS Units	WAC	AWP
83831-0116-01	500 MG / 1 ML Cyclophosphamide Intravenous Injection 500 MG/1ML - 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-116-01) / 1 mL in 1 VIAL, SINGLE-DOSE	Avyxa Pharma, LLC	100	$875.00 $8.75 / unit	$1,050.00 $10.50 / unit
83831-0117-02	1000 MG / 2 ML Cyclophosphamide Intravenous Injection 1000 MG/2ML - 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-117-02) / 2 mL in 1 VIAL, SINGLE-DOSE	Avyxa Pharma, LLC	200	$1,750.00 $8.75 / unit	$2,100.00 $10.50 / unit
83831-0118-04	2000 MG / 4 ML Cyclophosphamide Intravenous Injection 2000 MG/4ML - 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-118-04) / 4 mL in 1 VIAL, SINGLE-DOSE	Avyxa Pharma, LLC	400	$3,500.00 $8.75 / unit	$4,200.00 $10.50 / unit
83831-0119-01	500 MG / 1 ML Frindovyx Intravenous Injection 500 MG/1ML - 1 VIAL, MULTI-DOSE in 1 CARTON (83831-119-01) / 1 mL in 1 VIAL, MULTI-DOSE	Avyxa Pharma, LLC	100	$923.78 $9.238 / unit	$1,108.54 $11.085 / unit
83831-0120-02	1000 MG / 2 ML Frindovyx Intravenous Injection 1000 MG/2ML - 1 VIAL, MULTI-DOSE in 1 CARTON (83831-120-02) / 2 mL in 1 VIAL, MULTI-DOSE	Avyxa Pharma, LLC	200	$1,847.56 $9.238 / unit	$2,217.07 $11.085 / unit

Effective 4/1/26 (WAC & AWP)

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CYCLOPHOSPHAMIDE (AVYXA) Pricing & Reimbursement

J9072 Private Payer Reimbursement

$9.11 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

NDC Package

HCPCS Units

Markup / Markdown

%

Common:

Estimates only. Payer reimbursement varies by contract, site of care, and sequestration.

Estimated Reimbursement

Cyclophosphamide 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J9071	Eugia US	Cyclophosphamide	Injection, cyclophosphamide (auromedics), 5 mg
J9072	Avyxa Pharma	Cyclophosphamide	Injection, cyclophosphamide (frindovyx), 5 mg
J9073	Generic Code (Multiple Manufacturers)	Cyclophosphamide	Injection, cyclophosphamide (dr. reddy's), 5 mg
J9074	Sandoz	Cyclophosphamide	Injection, cyclophosphamide (sandoz), 5 mg
J9075	Generic Code (Multiple Manufacturers)	Cyclophosphamide	Injection, cyclophosphamide, not otherwise specified, 5 mg
J9076	Baxter Healthcare	Cyclophosphamide	Injection, cyclophosphamide (baxter), 5 mg

CYCLOPHOSPHAMIDE (AVYXA) Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 10.55%

Avg. Days to File 6.1days

Avg. Days to Pay 23.4days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9072 claims analytics on FocalPoint →

CYCLOPHOSPHAMIDE (AVYXA) CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Cyclophosphamide (avyxa) (J9072) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

CYCLOPHOSPHAMIDE (AVYXA) Medically Unlikely Edits (MUE)

The most billing units of J9072 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.

Practitioner Office & Hospital Outpatient

1,500 units / day

= 7,500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

CYCLOPHOSPHAMIDE (AVYXA) Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

acute lymphoblastic (stem-cell) leukemia acute myelogenous and monocytic leukemia adenocarcinoma of the ovary carcinoma of the breast chronic granulocytic leukemia chronic lymphocytic leukemia malignant lymphomas malignant lymphomas (Stages III and IV), Hodgkin's disease, lymphocytic lymphoma, mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma multiple myeloma mycosis fungoides mycosis fungoides (advanced disease) neuroblastoma neuroblastoma (disseminated disease) retinoblastoma

Frequently Asked Questions

Is there an available Cyclophosphamide (Avyxa) billing and coding guide?

Billing and coding information for CYCLOPHOSPHAMIDE (AVYXA) can be found through Avyxa Pharma. Visit Here →

Are there any available Cyclophosphamide (Avyxa) patient assistance programs?

CYCLOPHOSPHAMIDE (AVYXA) patient assistance information can be found through Avyxa Pharma. Visit Here →

Where can I find Cyclophosphamide (Avyxa) prescribing information?

CYCLOPHOSPHAMIDE (Avyxa) prescribing information can be found at the link below: Visit Here →

Where can I find Cyclophosphamide (Avyxa) side effect information?

Our team has not yet identified a source of side effects information for CYCLOPHOSPHAMIDE (Avyxa). Please check back in a few weeks.

Does billing CYCLOPHOSPHAMIDE (AVYXA) require JZ/JW wastage modifiers?

CMS has identified CYCLOPHOSPHAMIDE (AVYXA)(J9072) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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