BUPIVACAINE HCL J Code: J0665

Drug & Product Overview

HCPCS Descriptor Injection, bupivicaine, not otherwise specified, 0.5 mg

HCPCS Added Date July 1, 2023

Manufacturer Multiple Manufacturers

Route of Administration Epidural, Infiltration, Intracaudal, Perineural, Retrobulbar, Subarachnoid

Generic Status Multi-Source; Generic

Dosage Type Single-Dose, Multi-Dose

Dosage Form Injection | Injection, Solution

About BUPIVACAINE HCL

Bupivacaine HCL is a medication aligned to the HCPCS J Code: J0665 for billing, pricing, and reimbursement purposes in the United States. Classified under Anesthetic, it is administered via the epidural, infiltration, intracaudal, perineural, retrobulbar, or subarachnoid routes and manufactured by multiple companies.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 116 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9328-10	Bupivacaine Hydrochloride	Hikma Pharmaceuticals USA Inc.	2500	125 MG / 50 ML
00409-0525-25	Marcaine	Hospira, Inc.	12500	250 MG / 50 ML
00409-1559-10	Marcaine	Pfizer Inc	500	Marcaine Preservative Free Injection S… Login for More
50090-4516-00	Bupivacaine Hydrochloride	A-S Medication Solutions	500	250 MG / 50 ML
55150-0167-10	Bupivacaine Hydrochloride	Eugia US LLC	1250	25 MG / 10 ML
•••••-••••-•• Log in to view	BUPIVACAINE HCL
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BUPIVACAINE HCL Pricing & Reimbursement

J0665 Private Payer Reimbursement

$0.02 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Bupivicaine 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J0665	Generic Code (Multiple Manufacturers)	Bupivicaine	Injection, bupivicaine, not otherwise specified, 0.5 mg

BUPIVACAINE HCL CPT Administration Codes

CPT Code	Description
64483	Injection(s), anesthetic agent and/or steroid, transforaminal epidural; lumbar or sacral, single level.
20553	Injection(s); single or multiple trigger point(s), 3 or more muscles.
20552 Login for More	Injection(s); single or multiple trigger point(s), 1 or 2 muscle(s). Login for More

Not on the CMS JW / JZ list

CMS does not include Bupivacaine HCL (J0665) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0665. Wastage billing guide →

BUPIVACAINE HCL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Caudal anesthesia Dental block Epidural anesthesia Epidural test dose Local infiltration anesthesia Local or regional anesthesia for ophthalmic surgery (retrobulbar block) Local or regional anesthesia or analgesia Local or regional anesthesia or analgesia (caudal block) Local or regional anesthesia or analgesia (local infiltration) Local or regional anesthesia or analgesia (lumbar epidural block) Local or regional anesthesia or analgesia (peripheral nerve block) Local or regional anesthesia or analgesia (sympathetic block) Obstetrical anesthesia (epidural) Obstetrical epidural anesthesia Peripheral nerve block Retrobulbar block Subarachnoid block (spinal anesthesia) Sympathetic nerve block caudal anesthesia dental and oral surgery anesthesia dental and oral surgery anesthesia or analgesia dental and oral surgery anesthesia — dental blocks dental and oral surgery procedures dental anesthesia epidural anesthesia epidural anesthesia — test dose epidural test dose (obstetrical/epidural procedures) local infiltration anesthesia local or regional anesthesia or analgesia local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and obstetrical procedures local or regional anesthesia or analgesia for surgery, diagnostic and therapeutic procedures local or regional anesthesia or analgesia for surgery, oral surgery procedures, diagnostic and therapeutic procedures, and obstetrical procedures local or regional anesthesia or analgesia for surgery, oral surgery, diagnostic and therapeutic procedures, and obstetrical procedures local or regional anesthesia or analgesia for surgery, oral surgery, diagnostic and therapeutic, and obstetrical procedures local or regional anesthesia or analgesia — caudal local or regional anesthesia or analgesia — epidural local or regional anesthesia or analgesia — local infiltration local or regional anesthesia or analgesia — peripheral nerve block local or regional anesthesia or analgesia — retrobulbar block local or regional anesthesia or analgesia — sympathetic block obstetrical anesthesia — epidural obstetrical epidural anesthesia obstetrical procedures obstetrical procedures (epidural anesthesia) ophthalmic surgery peripheral nerve block retrobulbar block sympathetic block

Show all 48 conditions Show fewer

Drug Class

Amide Local Anesthetic [EPC]Amides [CS]Local Anesthesia [PE]

Frequently Asked Questions

Is there an available Bupivacaine Hcl billing and coding guide?

We have not yet identified a manufacturer source of Bupivacaine Hcl billing and coding information.

Are there any available Bupivacaine Hcl patient assistance programs?

Our team did not identify a source for Bupivacaine Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Bupivacaine Hcl prescribing information?

BUPIVACAINE HCL prescribing information can be found at the link below: Visit Here →

Where can I find Bupivacaine Hcl side effect information?

Our team has not yet identified a source of side effects information for BUPIVACAINE HCL. Please check back in a few weeks.

Does billing BUPIVACAINE HCL require JZ/JW wastage modifiers?

CMS does not include BUPIVACAINE HCL (J0665) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0665. For more information, visit the link below.

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