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Updated October 1st, 2026

EXPAREL J Code: J0666

Injection, bupivacaine liposome, 1 mg

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Medicare Payment Limit ?
$1.426
/ HCPCS billing unit
APC Payment Limit ?
$1.426
/ HCPCS billing unit · APC 0763
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
6
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Drug & Product Overview

HCPCS Descriptor Injection, bupivacaine liposome, 1 mg
HCPCS Added Date January 1, 2025
Manufacturer Pacira Pharmaceuticals
Route of Administration Infiltration
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Suspension, Liposomal

About EXPAREL

Exparel is a medication aligned to the HCPCS J Code: J0666 for billing, pricing, and reimbursement purposes in the United States. This Non-Opioid Analgesic medication is administered via the infiltration route and manufactured by Pacira Pharmaceuticals.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 4 of 6 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
65250-0133-04 Exparel Pacira Pharmaceuticals, Inc. 532 133 MG / 10 ML
65250-0133-09 Exparel Pacira Pharmaceuticals, Inc. 1330 133 MG / 10 ML
65250-0266-04 Exparel Pacira Pharmaceuticals, Inc. 1064 266 MG / 20 ML
65250-0266-09 Exparel Pacira Pharmaceuticals, Inc. 2660 266 MG / 20 ML
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EXPAREL
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EXPAREL Pricing & Reimbursement

J0666 Private Payer Reimbursement
$1.34 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q4 2026

Bupivacaine 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J0666 Pacira Pharmaceuticals Bupivacaine Injection, bupivacaine liposome, 1 mg

EXPAREL CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96375 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug.
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

EXPAREL Medically Unlikely Edits (MUE)

The most billing units of J0666 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
266 units / day
= 266 mg per day

MAI 2 · Date of Service Edit: Policy. Absolute per-day limit set by policy or regulation; units above it are not payable, and denials are not appealable on medical-necessity grounds. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

EXPAREL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Local analgesia via infiltration Regional analgesia via adductor canal block Regional analgesia via interscalene brachial plexus nerve block Regional analgesia via sciatic nerve block in the popliteal fossa
Drug Class
Amide Local Anesthetic [EPC]Amides [CS]Local Anesthesia [PE]

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Frequently Asked Questions

Is there an available EXPAREL billing and coding guide?
Billing and coding information for EXPAREL can be found through Pacira Pharmaceuticals, Inc.. Visit Here →
What are the available EXPAREL patient assistance programs?
EXPAREL patient assistance information can be found through Pacira Pharmaceuticals, Inc.. Visit Here →
Where can I find EXPAREL prescribing information?
EXPAREL prescribing information can be found at the link below. Visit Here →
Where can I find EXPAREL side effect information?
Our team has not identified a source of side effect information for EXPAREL
Does billing EXPAREL require JZ/JW wastage modifiers?
CMS does not include EXPAREL (J0666) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0666. For more information, visit the link below.

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