Home › Drug Codes › J Codes › J0668 · ZYNRELEF
Updated October 1st, 2026

ZYNRELEF J Code: J0668

Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q4 2026
APC Payment Limit ?
$0.848
/ HCPCS billing unit · APC 9440
ASP ?
No current ASP
Not available for Q4 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
HCPCS Added Date October 1, 2025
Manufacturer Heron Therapeutics
Route of Administration Infiltration
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Solution

About ZYNRELEF

Zynrelef is a medication aligned to the HCPCS J Code: J0668 for billing, pricing, and reimbursement purposes in the United States. Classified under Anesthetic, it is administered via the infiltration route and manufactured by Heron Therapeutics.

Manufacturers, reach out to us to add more information.

NDC Code Information

4 NDC packages are crosswalked to J0668. Package detail is available to logged-in subscribers.

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ZYNRELEF Pricing & Reimbursement

J0668 Private Payer Reimbursement
$0.60 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Bupivacaine And Meloxicam 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J0668 Heron Therapeutics Bupivacaine And Meloxicam Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg

ZYNRELEF CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96375 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug.
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

ZYNRELEF Medically Unlikely Edits (MUE)

The most billing units of J0668 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg - 0.03 mg.

Practitioner Office & Hospital Outpatient
400 units / day
= 400 mg - 0.03 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg - 0.03 mg Enter a dose to see how many billing units it is and whether it is under the limit.

ZYNRELEF Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures (including foot and ankle; avoid direct exposure to articular cartilage)
Drug Class
Amide Local Anesthetic [EPC]Amides [CS]Anti-Inflammatory AgentsNon-Steroidal [CS]Cyclooxygenase Inhibitors [MoA]Local Anesthesia [PE]Nonsteroidal Anti-inflammatory Drug [EPC]

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Frequently Asked Questions

Is there an available Zynrelef billing and coding guide?
Billing and coding information for ZYNRELEF can be found through Heron Therapeutics. Visit Here →
Are there any available Zynrelef patient assistance programs?
ZYNRELEF patient assistance information can be found through Heron Therapeutics. Visit Here →
Where can I find Zynrelef prescribing information?
Zynrelef prescribing information can be found through the link below. Visit Here →
Where can I find Zynrelef side effect information?
Our team has not yet identified a source of prescribing information for Zynrelef.
Does billing Zynrelef require wastage modifiers?
CMS does not include ZYNRELEF (J0668) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0668. For more information, visit the link below.

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