Home › Drug Codes › J Codes › J7190 · ALPHANATE
Updated July 1st, 2026

ALPHANATE J Code: J7190

Factor viii (antihemophilic factor, human) per i.u.

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Q4 2026 Medicare Payment Limit for J7190, effective October 1, 2026: $1.248 per HCPCS billing unit, up 0.2% from $1.246. From CMS's final file.

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Medicare Payment Limit ?
$1.246
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$1.246
/ HCPCS billing unit · APC 0925
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
16
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Drug & Product Overview

HCPCS Descriptor Factor viii (antihemophilic factor, human) per i.u.
HCPCS Added Date January 1, 1986
Manufacturer Multiple Manufacturers
Route of Administration Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Kit | Not Available

About ALPHANATE

Alphanate is a medication aligned to the HCPCS J Code: J7190 for billing, pricing, and reimbursement purposes in the United States. Classified under Hematology, it is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to control and prevent bleeding episodes in people with low levels of factor VIII (hemophilia A). It is also used in these patients before surgery to prevent bleeding. People with low factor VIII levels are at risk for bleeding longer after an injury/surgery and for bleeding inside the body (especially into the joints and muscles). This product contains human factor VIII, also called antihemophilic factor. This product is used to temporarily replace the missing factor VIII, a protein (clotting factor) that is normally in the blood, so that the blood can clot and the bleeding can stop.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 16 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00944-3940-02 Hemofil M Takeda Pharmaceuticals America, Inc. 1 Kit
00944-3942-02 Hemofil M Takeda Pharmaceuticals America, Inc. 1 Kit
00944-3944-02 Hemofil M Takeda Pharmaceuticals America, Inc. 1 Kit
00944-3946-02 Hemofil M Takeda Pharmaceuticals America, Inc. 1 Kit
76125-0257-25 Koate KEDRION BIOPHARMA, INC. 1 Kit
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ALPHANATE Pricing & Reimbursement

J7190 Private Payer Reimbursement
$1.08 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

ALPHANATE CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
JW / JZ modifiers apply

CMS has identified Alphanate (J7190) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ALPHANATE Medically Unlikely Edits (MUE)

The most billing units of J7190 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 iu.

Practitioner Office & Hospital Outpatient
22,000 units / day
= 22,000 iu per day

MAI 1 · Line Edit. Per-line limit: units are checked per claim line; medically necessary units beyond the limit may be billable on separate lines with appropriate modifiers. See all MUE limits →

iu Enter a dose to see how many billing units it is and whether it is under the limit.

ALPHANATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Hemophilia A Hemophilia A (hereditary Factor VIII deficiency)

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Frequently Asked Questions

Is there an available Alphanate billing and coding guide?
A billing and coding guide for Alphanate has not been identified by our team.
Are there any available Alphanate patient assistance programs?
Our team did not identify a source for Alphanate patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Alphanate prescribing information?
Our team is still working to identify a prescribing information source for ALPHANATE
Where can I find Alphanate side effect information?
Our team has not yet identified a source of side effects information for ALPHANATE. Please check back in a few weeks.
Does billing ALPHANATE require JZ/JW wastage modifiers?
CMS has identified ALPHANATE(J7190) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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Related Drug Codes

Explore billing, coding, and pricing for drugs related to ALPHANATE.

J7182NOVOEIGHTInjection, factor viii, (antihemophilic factor, recombinant), (novoeight), per iuNovo NordiskAdded January 1, 2015J7185XYNTHAInjection, factor viii (antihemophilic factor, recombinant) (xyntha), per i.u.PfizerAdded January 1, 2010J7187HUMATE-PInjection, von willebrand factor complex (humate-p), per iu vwf:rcoCSL BehringAdded January 1, 2007J7192ADVATEFactor viii (antihemophilic factor, recombinant) per i.u., not otherwise specifiedMultiple ManufacturersAdded January 1, 1994J7204ESPEROCTInjection, factor viii, antihemophilic factor (recombinant), (esperoct), glycopegylated-exei, per iuNovo NordiskAdded July 1, 2020J7209NUWIQInjection, factor viii, (antihemophilic factor, recombinant), (nuwiq), 1 i.u.OctapharmaAdded January 1, 2017J7210AFSTYLAInjection, factor viii, (antihemophilic factor, recombinant), (afstyla), 1 i.u.CSL BehringAdded January 1, 2018J7211KOVALTRYInjection, factor viii, (antihemophilic factor, recombinant), (kovaltry), 1 i.u.Bayer PharmaceuticalAdded January 1, 2018J2597DDAVPInjection, desmopressin acetate, per 1 mcgMultiple ManufacturersAdded January 1, 1996C9047CABLIVIInjection, caplacizumab-yhdp, 1 mgGenzymeAdded July 1, 2019