ALKERAN J Code: J9245

Drug & Product Overview

HCPCS Descriptor Injection, melphalan hydrochloride, not otherwise specified, 50 mg

HCPCS Added Date January 1, 1995

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Kit | Not Available

About ALKERAN

Alkeran is a medication aligned to the HCPCS J Code: J9245 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology, it is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: This medication is used to treat certain types of cancer (such as multiple myeloma, ovarian). Melphalan is also used as a pretreatment for people who are undergoing a stem cell transplant for multiple myeloma. Melphalan belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 18 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
23155-0355-41	Melphalan hydrochloride	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	1	Kit
25021-0258-61	Melphalan Hydrochloride	Sagent Pharmaceuticals	1	Kit
43598-0392-48	Melphalan Hydrochloride	Dr.Reddy's Laboratories Inc	1	Kit
45963-0686-02	Melphalan	Actavis Pharma, Inc.	1	50 MG
63323-0760-20	Melphalan	Fresenius Kabi USA, LLC	1	Kit
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ALKERAN Pricing & Reimbursement

J9245 Private Payer Reimbursement

$93.76 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ALKERAN CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

CMS does not include Alkeran (J9245) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9245. Wastage billing guide →

ALKERAN Medically Unlikely Edits (MUE)

The most billing units of J9245 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

9 units / day

= 450 mg per day

Hospital Outpatient

11 units / day

= 550 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ALKERAN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Multiple Myeloma

Frequently Asked Questions

Is there an available Alkeran billing and coding guide?

We have not yet identified a manufacturer source of Alkeran billing and coding information.

Are there any available Alkeran patient assistance programs?

Our team did not identify a source for Alkeran patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Alkeran prescribing information?

ALKERAN prescribing information can be found at the link below: Visit Here →

Where can I find Alkeran side effect information?

Information regarding ALKERAN's side effects can be found at MedlinePlus Visit Here →

Does billing ALKERAN require JZ/JW wastage modifiers?

CMS does not include ALKERAN (J9245) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9245. For more information, visit the link below.

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