OPTISON Q Code: Q9956

Drug & Product Overview

HCPCS Descriptor Injection, octafluoropropane microspheres, per ml

HCPCS Added Date April 1, 2005

Manufacturer GE Healthcare

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About OPTISON

Optison is a medication aligned to the HCPCS Q Code: Q9956 for billing, pricing, and reimbursement purposes in the United States. This Imaging/Radiopharmaceutical medication is administered via the intravenous route and manufactured by GE Healthcare.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00407-2707-03	Optison Perflutren Protein-Type A Microspheres	GE Healthcare Inc.	15	30 MG / 3 ML
00407-2707-18	Optison Perflutren Protein-Type A Microspheres	GE Healthcare Inc.	54	30 MG / 3 ML

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OPTISON Pricing & Reimbursement

Q9956 Private Payer Reimbursement

$40.90 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

OPTISON CPT Administration Codes

CPT Code	Description
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
96375	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); each additional sequential intravenous push of a new substance/drug.

Not on the CMS JW / JZ list

CMS does not include Optison (Q9956) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q9956. Wastage billing guide →

OPTISON Medically Unlikely Edits (MUE)

The most billing units of Q9956 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 ml.

Practitioner Office & Hospital Outpatient

9 units / day

= 9 ml per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

OPTISON Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Left ventricular opacification and endocardial border delineation in suboptimal echocardiograms

Drug Class

Contrast Agent for Ultrasound Imaging [EPC]Ultrasound Contrast Activity [MoA]

Frequently Asked Questions

Is there an available Optison billing and coding guide?

We have not yet identified a manufacturer source of Optison billing and coding information.

Are there any available Optison patient assistance programs?

Our team did not identify a source for Optison patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Optison prescribing information?

Our team is still working to identify a prescribing information source for OPTISON

Where can I find Optison side effect information?

Our team has not yet identified a source of side effects information for OPTISON. Please check back in a few weeks.

Does billing OPTISON require JZ/JW wastage modifiers?

CMS does not include OPTISON (Q9956) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q9956. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.