Home › Drug Codes › Q Codes › Q9957 · DEFINITY
Updated July 1st, 2026

DEFINITY Q Code: Q9957

Injection, perflutren lipid microspheres, per ml

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Q4 2026 Medicare Payment Limit for Q9957, effective October 1, 2026: $40.323 per HCPCS billing unit, down 1.3% from $40.854. From CMS's final file.

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Medicare Payment Limit ?
$40.854
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Injection, perflutren lipid microspheres, per ml
HCPCS Added Date April 1, 2005
Manufacturer Lantheus Medical Imaging
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Suspension

About DEFINITY

Definity is a medication aligned to the HCPCS Q Code: Q9957 for billing, pricing, and reimbursement purposes in the United States. It is an Imaging/Radiopharmaceutical drug administered via the intravenous route and manufactured by Lantheus Medical Imaging.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 3 of 4 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
11994-0011-04 Definity Lantheus Medical Imaging, Inc. 8 9.78 MG / 1.5 ML
11994-0011-16 Definity Lantheus Medical Imaging, Inc. 32 9.78 MG / 1.5 ML
11994-0017-20 Definity Rt Lantheus Medical Imaging, Inc. 40 2.282 MG / 0.35 ML
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DEFINITY Pricing & Reimbursement

Q9957 Private Payer Reimbursement
$41.63 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

DEFINITY CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
Not on the CMS JW / JZ list

CMS does not include Definity (Q9957) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q9957. Wastage billing guide →

DEFINITY Medically Unlikely Edits (MUE)

The most billing units of Q9957 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 ml.

Practitioner Office & Hospital Outpatient
3 units / day
= 3 ml per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ml Enter a dose to see how many billing units it is and whether it is under the limit.

DEFINITY Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Left ventricular opacification and endocardial border delineation
Drug Class
Contrast Agent for Ultrasound Imaging [EPC]Ultrasound Contrast Activity [MoA]

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Frequently Asked Questions

Is there an available Definity billing and coding guide?
Billing and coding information for DEFINITY can be found through Lantheus. Visit Here →
Are there any available Definity patient assistance programs?
DEFINITY patient assistance information can be found through Lantheus. Visit Here →
Where can I find Definity prescribing information?
DEFINITY prescribing information can be found at the link below: Visit Here →
Where can I find Definity side effect information?
Our team has not yet identified a source of side effects information for DEFINITY. Please check back in a few weeks.
Does billing DEFINITY require JZ/JW wastage modifiers?
CMS does not include DEFINITY (Q9957) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q9957. For more information, visit the link below.

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