NEOSTIGMINE METHYLSULFATE J Code: J2710

Drug & Product Overview

HCPCS Descriptor Injection, neostigmine methylsulfate, up to 0.5 mg

HCPCS Added Date January 1, 1982

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Multi-Dose

Dosage Form Injection | Injection, Solution

About NEOSTIGMINE METHYLSULFATE

Neostigmine Methylsulfate is a medication aligned to the HCPCS J Code: J2710 for billing, pricing, and reimbursement purposes in the United States. It is a Neurology drug administered via the intravenous route and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

32 NDC packages are crosswalked to J2710. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	NEOSTIGMINE METHYLSULFATE
	NEOSTIGMINE METHYLSULFATE
	NEOSTIGMINE METHYLSULFATE
	NEOSTIGMINE METHYLSULFATE

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NEOSTIGMINE METHYLSULFATE Pricing & Reimbursement

J2710 Private Payer Reimbursement

$0.56 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Neostigmine Methylsulfate 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2710	Generic Code (Multiple Manufacturers)	Neostigmine Methylsulfate	Injection, neostigmine methylsulfate, up to 0.5 mg
J2711	Generic Code (Multiple Manufacturers)	Neostigmine Methylsulfate	Injection, neostigmine methylsulfate 0.1 mg and glycopyrrolate 0.02 mg

NEOSTIGMINE METHYLSULFATE CPT Administration Codes

CPT Code	Description
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug

Not on the CMS JW / JZ list

CMS does not include Neostigmine Methylsulfate (J2710) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2710. Wastage billing guide →

NEOSTIGMINE METHYLSULFATE Medically Unlikely Edits (MUE)

The most billing units of J2710 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.5 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

2 units / day

= 1 mg per day

Hospital Outpatient

10 units / day

= 5 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

NEOSTIGMINE METHYLSULFATE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Reversal of effects of non-depolarizing neuromuscular blocking agents after surgery Reversal of effects of nondepolarizing neuromuscular blocking agents (NMBA) after surgery Reversal of non-depolarizing neuromuscular blocking agents Reversal of nondepolarizing neuromuscular blocking agents Reversal of nondepolarizing neuromuscular blocking agents after surgery Reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery reversal of the effects of nondepolarizing neuromuscular blocking agents after surgery

Drug Class

Cholinesterase Inhibitor [EPC]Cholinesterase Inhibitors [MoA]

Frequently Asked Questions

Is there an available Neostigmine Methylsulfate billing and coding guide?

We have not yet identified a manufacturer source of Neostigmine Methylsulfate billing and coding information.

Are there any available Neostigmine Methylsulfate patient assistance programs?

Our team did not identify a source for Neostigmine Methylsulfate patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Neostigmine Methylsulfate prescribing information?

NEOSTIGMINE METHYLSULFATE prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Neostigmine Methylsulfate side effect information?

Our team has not yet identified a source of side effects information for NEOSTIGMINE METHYLSULFATE. Please check back in a few weeks.

Does billing NEOSTIGMINE METHYLSULFATE require JZ/JW wastage modifiers?

CMS does not include NEOSTIGMINE METHYLSULFATE (J2710) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2710. For more information, visit the link below.

About BuyandBill.com:

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