Home › Drug Codes › J Codes › J2251 · Midazolam HCl
Updated July 1st, 2026

Midazolam HCl J Code: J2251

Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg

Login to unlock all benchmarks

Q4 2026 Medicare Payment Limit for J2251, effective October 1, 2026: $0.078 per HCPCS billing unit, down 33.3% from $0.117. From CMS's final file.

?
Medicare Payment Limit ?
$0.117
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
Login to view
WAC · AWP ?
$•••.••
Login to view
NDCs Crosswalked ?
10
View NDC crosswalk →

Drug & Product Overview

HCPCS Descriptor Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
HCPCS Added Date January 1, 2023
Manufacturer Multiple Manufacturers
Route of Administration Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection | Injection, Solution

About Midazolam HCl

Midazolam HCl is a medication aligned to the HCPCS J Code: J2251 for billing, pricing, and reimbursement purposes in the United States. It is a Sedative drug administered via the intravenous route and manufactured by multiple companies.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 10 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00143-9379-10 Midazolam in Sodium Chloride Hikma Pharmaceuticals USA Inc. 500 50 MG / 50 ML
00143-9380-10 Midazolam in Sodium Chloride Hikma Pharmaceuticals USA Inc. 1000 100 MG / 100 ML
25021-0688-82 Midazolam in Sodium Chloride Sagent Pharmaceuticals 500 50 MG / 50 ML
44567-0610-10 Midazolam in Sodium Chloride WG Critical Care, LLC. 500 50 MG / 50 ML
65219-0650-10 Midazolam In Sodium Chloride FRESENIUS KABI USA, LLC 1000 100 MG / 100 ML
•••••-••••-•• Log in to view Midazolam HCl
Midazolam HCl
Midazolam HCl
Login to view 5 more NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.
Login →

Midazolam HCl Pricing & Reimbursement

J2251 Private Payer Reimbursement
$0.44 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →
UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

Midazolam Hydrochloride 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J2250 Generic Code (Multiple Manufacturers) Midazolam Hydrochloride Injection, midazolam hydrochloride, per 1 mg
J2251 Generic Code (Multiple Manufacturers) Midazolam Hydrochloride Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
J2252 Generic Code (Multiple Manufacturers) Midazolam Hydrochloride Injection, midazolam in 0.8% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg

Midazolam HCl CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

CMS does not include Midazolam HCl (J2251) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2251. Wastage billing guide →

Midazolam HCl Medically Unlikely Edits (MUE)

The most billing units of J2251 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient
22 units / day
= 22 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

Midazolam HCl Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Sedation of intubated and mechanically ventilated patients
Drug Class
Benzodiazepine [EPC]Benzodiazepines [CS]

Login for BuyandBill.com Analytics

Unlock deeper insights with BuyandBill’s Comparative Report!

  • Compare ASP, WAC, and AWP across drugs.
  • Visualize Drug Price Movement Over Time
  • Tailor reports to drug class, manufacturer, or HCPCS Code.
  • Compare Biosimilar and 505(b)(2) products.
Access Full Report →

Frequently Asked Questions

Is there an available Midazolam Hcl billing and coding guide?
We have not yet identified a manufacturer source of Midazolam Hcl billing and coding information.
Are there any available Midazolam Hcl patient assistance programs?
Our team did not identify a source for Midazolam Hcl patient assistance information. Please reach out to our team if you feel that this is a mistake.
Where can I find Midazolam Hcl prescribing information?
Midazolam HCl prescribing information can be found at the link below: Visit Here →
Where can I find Midazolam Hcl side effect information?
Information regarding Midazolam HCl's side effects can be found at MedlinePlus Visit Here →
Does billing Midazolam HCl require JZ/JW wastage modifiers?
CMS does not include Midazolam HCl (J2251) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2251. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.

Related Drug Codes

Explore billing, coding, and pricing for drugs related to Midazolam HCl.

J2250MIDAZOLAM HCLInjection, midazolam hydrochloride, per 1 mgMultiple ManufacturersAdded January 1, 1996J2252MIDAZOLAM-SODIUM CHLORIDE (PF)Injection, midazolam in 0.8% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mgB. Braun Medical IncAdded October 1, 2024J3360DiazepamInjection, diazepam, up to 5 mgMultiple ManufacturersAdded January 1, 1982J2060ATIVANInjection, lorazepam, 2 mgMultiple ManufacturersAdded January 1, 1982J0300AMYTAL SODIUMInjection, amobarbital, up to 125 mgBAUSCH HEALTH USAdded January 1, 1982J1790DROPERIDOLInjection, droperidol, up to 5 mgMultiple ManufacturersAdded January 1, 1982J1990CHLORDIAZEPOXIDE HCLInjection, chlordiazepoxide hcl, up to 100 mgAdded January 1, 1982J2249BYFAVOInjection, remimazolam, 1 mgAcacia PharmaAdded July 1, 2023J2253SEIZALAMInjection, midazolam (seizalam), 1 mgMeridian Medical Technologies, IncAdded October 1, 2024J2515NEMBUTAL SODIUMInjection, pentobarbital sodium, per 50 mgMultiple ManufacturersAdded January 1, 1982