MIDAZOLAM HCL J Code: J2250
Injection, midazolam hydrochloride, per 1 mg
Q4 2026 Medicare Payment Limit for J2250, effective October 1, 2026: $0.167 per HCPCS billing unit, up 16.8% from $0.143. From CMS's final file.
Drug & Product Overview
About MIDAZOLAM HCL
Midazolam HCL is a medication aligned to the HCPCS J Code: J2250 for billing, pricing, and reimbursement purposes in the United States. This Sedative medication is administered via the intramuscular or intravenous routes and manufactured by multiple companies.
According to CMS Drug Use Information: Midazolam is used before surgery or a procedure. It helps to cause drowsiness, decrease anxiety, and to decrease your memory of the surgery or procedure. This medication may also be used to help with anesthesia or to sedate people who need a tube or machine to help with breathing. Midazolam works by calming the brain and nerves. It belongs to a class of drugs known as benzodiazepines.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 62 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00409-0001-25 | Midazolam | Hospira, Inc. | 50 | 2 MG / 2 ML |
| 00641-6056-10 | Midazolam | Hikma Pharmaceuticals USA Inc. | 100 | 10 MG / 10 ML |
| 23155-0600-41 | Midazolam hydrochloride | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 50 | 2 MG / 2 ML |
| 25021-0655-02 | midazolam | Sagent Pharmaceuticals | 20 | 2 MG / 2 ML |
| 50090-5342-00 | Midazolam Hydrochloride | A-S Medication Solutions | 500 | 50 MG / 10 ML |
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MIDAZOLAM HCL Pricing & Reimbursement
National median reimbursement across major commercial payers.
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Login to use the calculator →Midazolam Hydrochloride 505(b)(2) Information:
| HCPCS Code | Manufacturer | Active Ingredient | HCPCS Description |
|---|---|---|---|
| J2250 | Generic Code (Multiple Manufacturers) | Midazolam Hydrochloride | Injection, midazolam hydrochloride, per 1 mg |
| J2251 | Generic Code (Multiple Manufacturers) | Midazolam Hydrochloride | Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg |
| J2252 | Generic Code (Multiple Manufacturers) | Midazolam Hydrochloride | Injection, midazolam in 0.8% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg |
MIDAZOLAM HCL CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
| 96374 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug |
CMS does not include Midazolam HCL (J2250) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2250. Wastage billing guide →
MIDAZOLAM HCL Medically Unlikely Edits (MUE)
The most billing units of J2250 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg. The limit is different in the office and the hospital. Use the one for your setting.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
MIDAZOLAM HCL Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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