Dihydroergotamine Mesylate J Code: J1110

Drug & Product Overview

HCPCS Descriptor Injection, dihydroergotamine mesylate, per 1 mg

HCPCS Added Date January 1, 1982

Manufacturer Multiple Manufacturers

Route of Administration Intramuscular, Intravenous, Subcutaneous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Solution | Not Available

About Dihydroergotamine Mesylate

Dihydroergotamine Mesylate is a medication aligned to the HCPCS J Code: J1110 for billing, pricing, and reimbursement purposes in the United States. This Neurology medication is administered via the intramuscular, intravenous, or subcutaneous routes and manufactured by multiple companies.

According to CMS Drug Use Information: Dihydroergotamine is used to treat migraine headaches and cluster headaches. It is not recommended for migraines that affect only one side of the brain (hemiplegic migraine) or the base of the brain/neck area (basilar migraine), or to prevent migraines from occurring. Dihydroergotamine is an ergot medication that helps narrow widened blood vessels in the head, thereby reducing the throbbing effects of these headaches.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 7 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9273-10	Dihydroergotamine Mesylate	Hikma Pharmaceuticals USA Inc.	10	1 MG / 1 ML
00574-0850-05	Dihydroergotamine Mesylate	Padagis US LLC	5	1 MG
00574-0850-10	Dihydroergotamine Mesylate	Padagis US LLC	10	1 MG
61990-0411-01	Dihydroergotamine Mesylate	Apollo Pharmaceuticals Inc.	5	1 MG
81284-0411-05	Dihydroergotamine Mesylate	Provepharm Inc.	5	1 MG / 1 ML
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	Dihydroergotamine Mesylate

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Dihydroergotamine Mesylate Pricing & Reimbursement

J1110 Private Payer Reimbursement

$58.57 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Dihydroergotamine Mesylate CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
96374	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug

JW / JZ modifiers apply

CMS has identified Dihydroergotamine Mesylate (J1110) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

Dihydroergotamine Mesylate Medically Unlikely Edits (MUE)

The most billing units of J1110 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

3 units / day

= 3 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Dihydroergotamine Mesylate Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Cluster headache episodes Migraine headaches

Drug Class

Ergotamine Derivative [EPC]Ergotamines [CS]

Frequently Asked Questions

Is there an available Dihydroergotamine Mesylate billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for Dihydroergotamine Mesylate.

Are there any available Dihydroergotamine Mesylate patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for Dihydroergotamine Mesylate.

Where can I find Dihydroergotamine Mesylate prescribing information?

Dihydroergotamine Mesylate prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Dihydroergotamine Mesylate side effect information?

Our team has not yet identified a source of side effects information for Dihydroergotamine Mesylate. Please check back in a few weeks.

Does billing Dihydroergotamine Mesylate require JZ/JW wastage modifiers?

CMS has identified Dihydroergotamine Mesylate(J1110) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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