DEPO-ESTRADIOL J Code: J1000
Injection, depo-estradiol cypionate, up to 5 mg
Q4 2026 Medicare Payment Limit for J1000, effective October 1, 2026: $53.805 per HCPCS billing unit, unchanged from Q3 2026. From CMS's final file.
Drug & Product Overview
About DEPO-ESTRADIOL
Depo-estradiol is a medication aligned to the HCPCS J Code: J1000 for billing, pricing, and reimbursement purposes in the United States. It is a Hormone Replacement drug administered via the intramuscular route and manufactured by Pfizer.
According to CMS Drug Use Information: This medication is a hormone (estrogen). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. The list of NDCs below is not exhaustive.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00009-0271-01 | Depo-Estradiol | Pharmacia & Upjohn Company LLC | 5 | 25 MG / 5 ML |
DEPO-ESTRADIOL Pricing & Reimbursement
National median reimbursement across major commercial payers.
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The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96372 | Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular |
CMS does not include Depo-estradiol (J1000) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1000. Wastage billing guide →
DEPO-ESTRADIOL Medically Unlikely Edits (MUE)
The most billing units of J1000 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 5 mg.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
DEPO-ESTRADIOL Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
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Frequently Asked Questions
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Does billing DEPO-ESTRADIOL require JZ/JW wastage modifiers?
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