CINRYZE J Code: J0598

Drug & Product Overview

HCPCS Descriptor Injection, c-1 esterase inhibitor (human), cinryze, 10 units

HCPCS Added Date January 1, 2010

Manufacturer Takeda Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Kit

About CINRYZE

Cinryze is a medication aligned to the HCPCS J Code: J0598 for billing, pricing, and reimbursement purposes in the United States. It is an Immunology drug administered via the intravenous route and manufactured by Takeda Pharmaceuticals.

According to CMS Drug Use Information: This medication is used to help prevent swelling problems that occur with a certain immune disease passed down through families (hereditary angioedema-HAE). HAE is caused by low levels or improper function of a natural substance produced by the body (C1-inhibitor). Symptoms such as rapid swelling of the hands, feet, limbs, face, tongue, or throat can occur. Swelling of the intestinal tract may cause symptoms such as abdominal cramps, diarrhea, or vomiting. Attacks of swelling may occur without reason. However, anxiety, stress, sickness, and surgery may trigger attacks in some people. This medication increases the level of C1-inhibitor to help prevent attacks of sudden swelling due to hereditary angioedema.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
42227-0083-01	Cinryze	Takeda Pharmaceuticals America, Inc.	50	Kit

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CINRYZE Pricing & Reimbursement

J0598 Private Payer Reimbursement

$65.50 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

CINRYZE CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Cinryze (J0598) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

CINRYZE Medically Unlikely Edits (MUE)

The most billing units of J0598 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 units.

Practitioner Office & Hospital Outpatient

100 units / day

= 1,000 units per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

CINRYZE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Hereditary Angioedema (HAE)

Frequently Asked Questions

Is there an available Cinryze billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for CINRYZE.

Are there any available Cinryze patient assistance programs?

CINRYZE patient assistance information can be found through Takeda. Visit Here →

Where can I find Cinryze prescribing information?

CINRYZE prescribing information can be found at the link below: Visit Here →

Where can I find Cinryze side effect information?

Information regarding CINRYZE's side effects can be found at MedlinePlus Visit Here →

Does billing CINRYZE require JZ/JW wastage modifiers?

CMS has identified CINRYZE(J0598) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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