TAKHZYRO J Code: J0593

Self-Administered Drug Exclusion 6 Medicare Administrative Contractors list J0593 as usually self-administered and exclude it from Part B coverage in their jurisdictions. Check the article for your MAC before billing: CGS, First Coast, Noridian (A53032), Noridian (A53033), Novitas, Wellpoint Federal, WPS · All SAD lists →

Drug & Product Overview

HCPCS Descriptor Injection, lanadelumab-flyo, 1 mg (code may be used for medicare when drug administered under direct supervision of a physician, not for use when drug is self-administered)

HCPCS Added Date October 1, 2019

Manufacturer Takeda Pharmaceuticals

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Solution

About TAKHZYRO

Takhzyro is a medication aligned to the HCPCS J Code: J0593 for billing, pricing, and reimbursement purposes in the United States. Classified under Immunology, it is administered via the subcutaneous route and manufactured by Takeda Pharmaceuticals.

Manufacturers, reach out to us to add more information.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
47783-0645-01	Takhzyro	Takeda Pharmaceuticals America, Inc.	150	150 MG / 1 ML
47783-0646-01	Takhzyro	Takeda Pharmaceuticals America, Inc.	300	300 MG / 2 ML

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TAKHZYRO Pricing & Reimbursement

J0593 Private Payer Reimbursement

$87.35 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

TAKHZYRO CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

Not on the CMS JW / JZ list

CMS does not include Takhzyro (J0593) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0593. Wastage billing guide →

TAKHZYRO Medically Unlikely Edits (MUE)

The most billing units of J0593 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 300 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

TAKHZYRO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Hereditary angioedema (HAE)

Drug Class

Kallikrein Inhibitors [MoA]Plasma Kallikrein Inhibitor [EPC]

Frequently Asked Questions

Is there an available Takhzyro billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for TAKHZYRO.

Are there any available Takhzyro patient assistance programs?

TAKHZYRO patient assistance information can be found through Takeda. Visit Here →

Where can I find Takhzyro prescribing information?

TAKHZYRO prescribing information can be found at the link below: Visit Here →

Where can I find Takhzyro side effect information?

Information regarding TAKHZYRO's side effects can be found at MedlinePlus Visit Here →

Does billing TAKHZYRO require JZ/JW wastage modifiers?

CMS does not include TAKHZYRO (J0593) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0593. For more information, visit the link below.

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