Home › Drug Codes › J Codes › J0280 · AMINOPHYLLINE
Updated July 1st, 2026

AMINOPHYLLINE J Code: J0280

Injection, aminophyllin, up to 250 mg

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Q4 2026 Medicare Payment Limit for J0280, effective October 1, 2026: $10.757 per HCPCS billing unit, down 3.6% from $11.16. From CMS's final file.

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Medicare Payment Limit ?
$11.16
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
4
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Drug & Product Overview

HCPCS Descriptor Injection, aminophyllin, up to 250 mg
HCPCS Added Date January 1, 1984
Manufacturer Hospira
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution

About AMINOPHYLLINE

Aminophylline is a medication aligned to the HCPCS J Code: J0280 for billing, pricing, and reimbursement purposes in the United States. It is a Respiratory drug administered via the intravenous route and manufactured by Hospira.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 4 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00409-5921-01 Aminophylline Hospira, Inc. 25 250 MG / 10 ML
00409-5922-01 Aminophylline Hospira, Inc. 50 500 MG / 20 ML
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AMINOPHYLLINE
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AMINOPHYLLINE Pricing & Reimbursement

J0280 Private Payer Reimbursement
$10.31 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

AMINOPHYLLINE CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
JW / JZ modifiers apply

CMS has identified Aminophylline (J0280) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

AMINOPHYLLINE Medically Unlikely Edits (MUE)

The most billing units of J0280 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 250 mg. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office
7 units / day
= 1,750 mg per day
Hospital Outpatient
10 units / day
= 2,500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

AMINOPHYLLINE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

acute exacerbations of asthma and other chronic lung diseases (e.g., emphysema and chronic bronchitis)
Drug Class
Methylxanthine [EPC]Xanthines [CS]

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Frequently Asked Questions

Is there an available Aminophylline billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for AMINOPHYLLINE.
Are there any available Aminophylline patient assistance programs?
AMINOPHYLLINE patient assistance information can be found through Pfizer. Visit Here →
Where can I find Aminophylline prescribing information?
AMINOPHYLLINE prescribing information can be found at the link below: Visit Here →
Where can I find Aminophylline side effect information?
Information regarding AMINOPHYLLINE's side effects can be found at MedlinePlus Visit Here →
Does billing AMINOPHYLLINE require JZ/JW wastage modifiers?
CMS has identified AMINOPHYLLINE(J0280) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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