ZIIHERA J Code: J9276

Drug & Product Overview

HCPCS Descriptor Injection, zanidatamab-hrii, 2 mg

HCPCS Added Date July 1, 2025

Manufacturer Jazz Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About ZIIHERA

Ziihera is a medication aligned to the HCPCS J Code: J9276 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by Jazz Pharmaceuticals.

According to CMS Drug Use Information: This medication is used to treat biliary tract cancer. Zanidatamab belongs to a class of drugs known as monoclonal antibodies. Zanidatamab works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 2 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
68727-0950-02	Ziihera	Jazz Pharmaceuticals, Inc.	300	300 MG / 6 ML
•••••-••••-•• Log in to view	ZIIHERA

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ZIIHERA Pricing & Reimbursement

J9276 Private Payer Reimbursement

$25.73 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

ZIIHERA Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 25.49%

Avg. Days to File 5.5days

Avg. Days to Pay 28.5days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9276 claims analytics on FocalPoint →

ZIIHERA CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

ZIIHERA Medically Unlikely Edits (MUE)

The most billing units of J9276 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 2 mg.

Practitioner Office & Hospital Outpatient

1,500 units / day

= 3,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ZIIHERA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Biliary Tract Cancer Gastric, gastroesophageal junction, or esophageal adenocarcinoma

Drug Class

Bispecific HER2-directed Antibody [EPC]HER2-directed Antibody Interactions [MoA]

Frequently Asked Questions

Is there an available ZIIHERA billing and coding guide?

Billing and coding information for ZIIHERA can be found through Jazz Pharmaceuticals, Inc.. Visit Here →

Are there any available ZIIHERA patient assistance programs?

ZIIHERA patient assistance information can be found through Jazz Pharmaceuticals, Inc.. Visit Here →

Where can I find ZIIHERA prescribing information?

ZIIHERA prescribing information can be found at the link below. Visit Here →

Where can I find ZIIHERA side effect information?

We have not identified a source of side effect information for ZIIHERA.

Does billing ZIIHERA require JZ/JW wastage modifiers?

CMS does not include ZIIHERA (J9276) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9276. For more information, visit the link below.

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