ZALTRAP J Code: J9400

Drug & Product Overview

HCPCS Descriptor Injection, ziv-aflibercept, 1 mg

HCPCS Added Date January 1, 2014

Manufacturer Sanofi

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Solution, Concentrate

About ZALTRAP

Zaltrap is a medication aligned to the HCPCS J Code: J9400 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by Sanofi.

According to CMS Drug Use Information: Ziv-aflibercept is used to treat cancer of the colon and rectum.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00024-5840-01	Zaltrap	sanofi-aventis U.S. LLC	100	100 MG / 4 ML
00024-5841-01	Zaltrap	sanofi-aventis U.S. LLC	200	200 MG / 8 ML

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ZALTRAP Pricing & Reimbursement

J9400 Private Payer Reimbursement

$7.68 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ZALTRAP Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 24.5%

Avg. Days to File 14.8days

Avg. Days to Pay 26.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9400 claims analytics on FocalPoint →

ZALTRAP CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Zaltrap (J9400) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ZALTRAP Medically Unlikely Edits (MUE)

The most billing units of J9400 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

500 units / day

= 500 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ZALTRAP Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Metastatic Colorectal Cancer

Drug Class

Vascular Endothelial Growth Factor Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitors [MoA]

Frequently Asked Questions

Is there an available Zaltrap billing and coding guide?

Billing and coding information for ZALTRAP can be found through Sanofi. Visit Here →

Are there any available Zaltrap patient assistance programs?

ZALTRAP patient assistance information can be found through Sanofi. Visit Here →

Where can I find Zaltrap prescribing information?

ZALTRAP prescribing information can be found at the link below: Visit Here →

Where can I find Zaltrap side effect information?

Information regarding ZALTRAP's side effects can be found at MedlinePlus Visit Here →

Does billing ZALTRAP require JZ/JW wastage modifiers?

CMS has identified ZALTRAP(J9400) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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