Home Drug Codes J Codes J0588 · XEOMIN
Updated July 1st, 2026

XEOMIN J Code: J0588

Injection, incobotulinumtoxin a, 1 unit

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Q4 2026 Medicare Payment Limit for J0588, effective October 1, 2026: $5.262 per HCPCS billing unit, down 0.4% from $5.285. From CMS's final file.

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Medicare Payment Limit ?
$5.285
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$5.285
/ HCPCS billing unit · APC 9278
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
3
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Drug & Product Overview

HCPCS Descriptor Injection, incobotulinumtoxin a, 1 unit
HCPCS Added Date January 1, 2012
Manufacturer Merz Pharmaceuticals
Route of Administration Intramuscular
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Powder, Lyophilized, For Solution

About XEOMIN

Xeomin is a medication aligned to the HCPCS J Code: J0588 for billing, pricing, and reimbursement purposes in the United States. This Neurology medication is administered via the intramuscular route and manufactured by Merz Pharmaceuticals.

According to CMS Drug Use Information: There are different types of botulinum toxin products (toxin A and B) with different uses (eye problems, muscle stiffness/spasms, migraines, cosmetic, overactive bladder). Different brands of this medication deliver different amounts of medication. Your doctor will choose the correct product for you. Botulinum toxin is used to treat certain eye disorders such as crossed eyes (strabismus) and uncontrolled blinking (blepharospasm), to treat muscle stiffness/spasms or movement disorders (such as cervical dystonia, torticollis), and to reduce the cosmetic appearance of wrinkles or vertical neck bands connecting the jaw and neck (platysma bands). It is also used to prevent headaches in people with very frequent migraines. Botulinum toxin relaxes muscle by blocking the release of a chemical called acetylcholine. Botulinum toxin is also used to treat overactive bladder by patients who do not respond to or who cannot tolerate the side effects of other medications. It helps to reduce leaking of urine, feeling of needing to urinate right away, and frequent trips to the bathroom. It is also used to treat severe underarm sweating and drooling/excess saliva. Botulinum toxin works by blocking the chemicals that turn on the sweat and salivary glands. Botulinum toxin is not a cure, and your symptoms will gradually return as the medication wears off.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
00259-1605-01 Xeomin Merz Pharmaceuticals, LLC 50 Xeomin Intramuscular I njection 50 [USP… Login for More
00259-1610-01 Xeomin Merz Pharmaceuticals, LLC 100 Xeomin Intramuscular I njection 100 [US… Login for More
00259-1620-01 Xeomin Merz Pharmaceuticals, LLC 200 Xeomin Intramuscular I njection 200 [US… Login for More
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XEOMIN Pricing & Reimbursement

J0588 Private Payer Reimbursement
$5.38 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

XEOMIN CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96372 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular
JW / JZ modifiers apply

CMS has identified Xeomin (J0588) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

XEOMIN Medically Unlikely Edits (MUE)

The most billing units of J0588 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 unit.

Practitioner Office & Hospital Outpatient
600 units / day
= 600 unit per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

unit Enter a dose to see how many billing units it is and whether it is under the limit.

XEOMIN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Blepharospasm Cervical dystonia Chronic sialorrhea Glabellar lines Horizontal forehead lines Lateral canthal lines Upper facial lines (glabellar lines, horizontal forehead lines, and lateral canthal lines) Upper limb spasticity
Drug Class
Acetylcholine Release Inhibitor [EPC]Acetylcholine Release Inhibitors [MoA]Neuromuscular Blockade [PE]Neuromuscular Blocker [EPC]

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Frequently Asked Questions

Is there an available Xeomin billing and coding guide?
Billing and coding information for XEOMIN can be found through Merz. Visit Here →
Are there any available Xeomin patient assistance programs?
XEOMIN patient assistance information can be found through Merz. Visit Here →
Where can I find Xeomin prescribing information?
XEOMIN prescribing information can be found at the link below: Visit Here →
Where can I find Xeomin side effect information?
Information regarding XEOMIN's side effects can be found at MedlinePlus Visit Here →
Does billing XEOMIN require JZ/JW wastage modifiers?
CMS has identified XEOMIN(J0588) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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