ROMIDEPSIN J Code: J9318

Drug & Product Overview

HCPCS Descriptor Injection, romidepsin, non-lyophilized, 0.1 mg

HCPCS Added Date October 1, 2021

Manufacturer Amneal Biosciences

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Form Injection, Solution, Concentrate | Not Available

About ROMIDEPSIN

Romidepsin is a medication aligned to the HCPCS J Code: J9318 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by Amneal Biosciences.

According to CMS Drug Use Information: Romidepsin is used to treat a certain type of cancer (cutaneous T-cell lymphoma). Romidepsin works by stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Package	Manufacturer	HCPCS Units	WAC	AWP
70121-2250-01	27.5 MG / 5.5 ML Romidepsin Intravenous Injection 27.5 MG/5.5ML - 1 VIAL in 1 CARTON (70121-2250-1) / 5.5 mL in 1 VIAL	Amneal Pharmaceuticals LLC	275	$8,700.00 $31.636 / unit	$10,440.00 $37.964 / unit

Effective 6/10/26 (WAC & AWP)

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ROMIDEPSIN Pricing & Reimbursement

J9318 Private Payer Reimbursement

$29.53 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

NDC Package

HCPCS Units

Markup / Markdown

%

Common:

Estimates only. Payer reimbursement varies by contract, site of care, and sequestration.

Estimated Reimbursement

ROMIDEPSIN CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Romidepsin (J9318) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ROMIDEPSIN Medically Unlikely Edits (MUE)

The most billing units of J9318 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient

475 units / day

= 47.5 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ROMIDEPSIN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Cutaneous T-cell lymphoma (CTCL)

Drug Class

Bile Salt Export Pump Inhibitors [MoA]Histone Deacetylase Inhibitor [EPC]Histone Deacetylase Inhibitors [MoA]Organic Anion Transporter 1 Inhibitors [MoA]Organic Anion Transporting Polypeptide 1B1 Inhibitors [MoA]Organic Anion Transporting Polypeptide 1B3 Inhibitors [MoA]Organic Cation Transporter 2 Inhibitors [MoA]

Frequently Asked Questions

Is there an available Romidepsin billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for ROMIDEPSIN.

Are there any available Romidepsin patient assistance programs?

ROMIDEPSIN patient assistance information can be found through Amneal Biosciences. Visit Here →

Where can I find Romidepsin prescribing information?

ROMIDEPSIN prescribing information can be found at the link below: Visit Here →

Where can I find Romidepsin side effect information?

Information regarding ROMIDEPSIN's side effects can be found at MedlinePlus Visit Here →

Does billing ROMIDEPSIN require JZ/JW wastage modifiers?

CMS has identified ROMIDEPSIN(J9318) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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