ISTODAX J Code: J9319

Drug & Product Overview

HCPCS Descriptor Injection, romidepsin, lyophilized, 0.1 mg

HCPCS Added Date October 1, 2021

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Kit | Not Available

About ISTODAX

Istodax is a medication aligned to the HCPCS J Code: J9319 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Romidepsin is used to treat a certain type of cancer (cutaneous T-cell lymphoma). Romidepsin works by stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 3 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
59572-0984-01	Istodax	Celgene Corporation	100	Kit
63323-0926-88	Romidepsin	Fresenius Kabi USA, LLC	100	Kit
•••••-••••-•• Log in to view	ISTODAX

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ISTODAX Pricing & Reimbursement

J9319 Private Payer Reimbursement

$31.81 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

ISTODAX CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Istodax (J9319) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ISTODAX Medically Unlikely Edits (MUE)

The most billing units of J9319 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient

500 units / day

= 50 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ISTODAX Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Cutaneous T-cell lymphoma (CTCL)

Frequently Asked Questions

Is there an available Istodax billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for ISTODAX.

Are there any available Istodax patient assistance programs?

Our team has not identified a manufacturer-published source of patient assistance information for ISTODAX.

Where can I find Istodax prescribing information?

ISTODAX prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Istodax side effect information?

Our team has not yet identified a source of side effects information for ISTODAX. Please check back in a few weeks.

Does billing ISTODAX require JZ/JW wastage modifiers?

CMS has identified ISTODAX(J9319) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

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