REBIF Q Code: Q3028

Self-Administered Drug Exclusion 5 Medicare Administrative Contractors list Q3028 as usually self-administered and exclude it from Part B coverage in their jurisdictions. Check the article for your MAC before billing: CGS, Noridian (A53032), Noridian (A53033), Palmetto, Wellpoint Federal, WPS · All SAD lists →

Drug & Product Overview

HCPCS Descriptor Injection, interferon beta-1a, 1 mcg for subcutaneous use

HCPCS Added Date January 1, 2014

Manufacturer EMD Serono

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution | Kit

About REBIF

Rebif is a medication aligned to the HCPCS Q Code: Q3028 for billing, pricing, and reimbursement purposes in the United States. Classified under Neurology, it is administered via the subcutaneous route and manufactured by EMD Serono.

Manufacturers, reach out to us to add more information.

NDC Code Information

5 NDC packages are crosswalked to Q3028. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	REBIF
	REBIF
	REBIF
	REBIF

Login to view 5 NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.

REBIF Pricing & Reimbursement

Q3028 Private Payer Reimbursement

$41.88 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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REBIF CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

Not on the CMS JW / JZ list

CMS does not include Rebif (Q3028) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q3028. Wastage billing guide →

REBIF Medically Unlikely Edits (MUE)

The most billing units of Q3028 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mcg.

Practitioner Office & Hospital Outpatient

0 units / day

Not payable in this setting

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

REBIF Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

relapsing forms of multiple sclerosis

Drug Class

Interferon beta [EPC]Interferon-beta [CS]

Frequently Asked Questions

Is there an available Rebif billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for REBIF.

Are there any available Rebif patient assistance programs?

REBIF patient assistance information can be found through EMD Serono. Visit Here →

Where can I find Rebif prescribing information?

REBIF prescribing information can be found at the link below: Visit Here →

Where can I find Rebif side effect information?

Information regarding REBIF's side effects can be found at MedlinePlus Visit Here →

Does billing REBIF require JZ/JW wastage modifiers?

CMS does not include REBIF (Q3028) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing Q3028. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.