Home Drug Codes J Codes J2725 · PROTIRELIN
Updated July 1st, 2026

PROTIRELIN J Code: J2725

Injection, protirelin, per 250 mcg

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Medicare Payment Limit ?
Not published
CMS publishes none for Q3 2026
APC Payment Limit ?
Not published
CMS publishes none for Q3 2026
ASP ?
No current ASP
Not available for Q3 2026
WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
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Drug & Product Overview

HCPCS Descriptor Injection, protirelin, per 250 mcg
HCPCS Added Date January 1, 1995
Route of Administration Intravenous
Generic Status Single-Source; Branded

About PROTIRELIN

Protirelin is a medication aligned to the HCPCS J Code: J2725 for billing, pricing, and reimbursement purposes in the United States. It is an Endocrinology drug administered via the intravenous route.

Manufacturers, reach out to us to add more information.

NDC Code Information

No NDC packages are aligned to J2725 in publicly available CMS files.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
No public NDC alignments
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PROTIRELIN Pricing & Reimbursement

J2725 Private Payer Reimbursement
$21.29 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

PROTIRELIN CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

CMS does not include Protirelin (J2725) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2725. Wastage billing guide →

PROTIRELIN Medically Unlikely Edits (MUE)

The most billing units of J2725 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 250 mcg.

Practitioner Office & Hospital Outpatient
0 units / day
Not payable in this setting

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

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Frequently Asked Questions

Is there an available Protirelin billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for Protirelin. Please reach out to us if this is a mistake.
Are there any available Protirelin patient assistance programs?
Our team has not identified a source of patient assistance information for Protirelin. Please reach out to us if this is a mistake.
Where can I find Protirelin prescribing information?
No available source of prescribing information for Protirelin
Where can I find Protirelin side effect information?
A link for Protirelin side effect information is not available.
Does billing Protirelin require JZ/JW wastage modifiers?
CMS does not include PROTIRELIN (J2725) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2725. For more information, visit the link below.

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