MANNITOL J Code: J2151

Drug & Product Overview

HCPCS Descriptor Injection, mannitol, 250 mg

HCPCS Added Date October 1, 2025

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection, Solution

About MANNITOL

Mannitol is a medication aligned to the HCPCS J Code: J2151 for billing, pricing, and reimbursement purposes in the United States. This Diuretic medication is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 4 of 7 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00409-4031-01	Mannitol	Hospira, Inc.	1250	12500 MG / 50 ML
00990-7715-02	Mannitol	ICU Medical Inc.	4800	50000 MG / 250 ML
00990-7715-03	Mannitol	ICU Medical Inc.	4800	100000 MG / 500 ML
63323-0024-25	Mannitol	Fresenius Kabi USA, LLC	1250	12500 MG / 50 ML
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MANNITOL Pricing & Reimbursement

J2151 Private Payer Reimbursement

$0.06 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Mannitol 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J2151	Generic Code (Multiple Manufacturers)	Mannitol	Injection, mannitol, 250 mg

MANNITOL CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

MANNITOL Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute renal failure (oliguric phase) — prevention Acute renal failure (oliguric phase) — prevention/treatment Acute renal failure (oliguric phase) — treatment Elevated intraocular pressure reduction Intracranial Pressure Reduction and Cerebral Edema Treatment Intracranial pressure reduction / cerebral edema Intracranial pressure reduction and cerebral edema treatment Intraocular Pressure Reduction Intraocular pressure reduction Reduction of elevated intraocular pressure Reduction of intracranial pressure and treatment of cerebral edema Urinary excretion of toxic substances Urologic irrigation (transurethral prostatic resection)

Drug Class

Increased Diuresis [PE]Osmotic Activity [MoA]Osmotic Diuretic [EPC]

Frequently Asked Questions

Is there an available Mannitol billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for Mannitol.

Are there any available Mannitol patient assistance programs?

Our team has not identified a manufacturer-published source of patient assitance information for Mannitol.

Where can I find Mannitol prescribing information?

Mannitol prescribing information can be found through the link below. Visit Here →

Where can I find Mannitol side effect information?

Our team has not yet identified a source of prescribing information for Mannitol.

Does billing Mannitol require wastage modifiers?

CMS does not include MANNITOL (J2151) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2151. For more information, visit the link below.

About BuyandBill.com:

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