Home › Drug Codes › J Codes › J0650 · Levothyroxine Sodium
Updated October 1st, 2026

Levothyroxine Sodium J Code: J0650

Injection, levothyroxine sodium, not otherwise specified, 10 mcg

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Medicare Payment Limit ?
$6.581
/ HCPCS billing unit
APC Payment Limit ?
Not published
CMS publishes none for Q4 2026
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
18
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Drug & Product Overview

HCPCS Descriptor Injection, levothyroxine sodium, not otherwise specified, 10 mcg
HCPCS Added Date April 1, 2024
Manufacturer Multiple Manufacturers
Route of Administration Intravenous
Generic Status Multi-Source; Generic
Dosage Type Single-Dose
Dosage Form Injection, Powder, Lyophilized, For Solution | Not Available

About Levothyroxine Sodium

Levothyroxine Sodium is a medication aligned to the HCPCS J Code: J0650 for billing, pricing, and reimbursement purposes in the United States. Classified under Endocrinology, it is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 18 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
25021-0468-10 Levothyroxine Sodium Sagent Pharmaceuticals 10 100 MCG / 5 ML
42023-0201-01 Levothyroxine Sodium ENDO USA, Inc. 10 100 MCG / 5 ML
63323-0647-10 Levothyroxine Sodium Fresenius Kabi USA, LLC 20 200 MCG / 5 ML
70710-1833-01 Levothyroxine Sodium Zydus Pharmaceuticals USA Inc. 10 100 MCG / 5 ML
70860-0451-10 Levothyroxine Sodium Athenex Pharmaceutical Division, LLC 10 100 MCG
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Levothyroxine Sodium
Levothyroxine Sodium
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Levothyroxine Sodium Pricing & Reimbursement

J0650 Private Payer Reimbursement
$5.97 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q4 2026

Levothyroxine Sodium 505(b)(2) Information:

HCPCS Code Manufacturer Active Ingredient HCPCS Description
J0650 Generic Code (Multiple Manufacturers) Levothyroxine Sodium Injection, levothyroxine sodium, not otherwise specified, 10 mcg
J0651 Fresenius Kabi Levothyroxine Sodium Injection, levothyroxine sodium (fresenius kabi), not therapeutically equivalent to j0650, 10 mcg
J0652 Hikma Levothyroxine Sodium Injection, levothyroxine sodium (hikma), not therapeutically equivalent to j0650, 10 mcg

Levothyroxine Sodium CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96374 Therapeutic, prophylactic, or diagnostic injection (specify substance or drug), IV push, single, or initial substance/drug
Not on the CMS JW / JZ list

This product is new and does not yet appear on the CMS list of HCPCS pertaining to single-dose containers. Wastage billing guide →

Levothyroxine Sodium Medically Unlikely Edits (MUE)

The most billing units of J0650 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mcg.

Practitioner Office & Hospital Outpatient
100 units / day
= 1,000 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

Levothyroxine Sodium Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Myxedema coma
Drug Class
Thyroxine [CS]l-Thyroxine [EPC]

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Frequently Asked Questions

Is there an available Levothyroxine Sodium billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for Levothyroxine Sodium.
Are there any available Levothyroxine Sodium patient assistance programs?
Our team has not identified a manufacturer-published source of patient assistance information for Levothyroxine Sodium.
Where can I find RYKINDO prescribing information?
Levothyroxine Sodium prescribing information can be found at the link below: Visit Here →
Where can I find Levothyroxine Sodium side effect information?
Our team has not yet identified a source of side effect information for Levothyroxine Sodium.
Does billing Levothyroxine Sodium require JZ/JW wastage modifiers?
CMS does not include Levothyroxine Sodium (J0650) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J0650. For more information, visit the link below.

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