KEPPRA J Code: J1953

Drug & Product Overview

HCPCS Descriptor Injection, levetiracetam, 10 mg

HCPCS Added Date January 1, 2009

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Solution | Injection, Solution, Concentrate | Not Available

About KEPPRA

Keppra is a medication aligned to the HCPCS J Code: J1953 for billing, pricing, and reimbursement purposes in the United States. This Neurology medication is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 75 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00143-9281-10	Levetiracetam in Sodium Chloride	Hikma Pharmaceuticals USA Inc.	500	500 MG / 100 ML
00264-1009-90	Levetiracetam	B. Braun Medical Inc.	2400	1000 MG / 100 ML
00409-1886-02	Levetiracetam	Hospira, Inc.	1250	500 MG / 5 ML
14789-0110-05	Levetiracetam in Sodium Chloride	Nexus Pharmaceuticals LLC	500	500 MG / 100 ML
25021-0780-05	Levetiracetam	Sagent Pharmaceuticals	500	500 MG / 5 ML
•••••-••••-•• Log in to view	KEPPRA
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KEPPRA Pricing & Reimbursement

J1953 Private Payer Reimbursement

$0.04 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

KEPPRA CPT Administration Codes

CPT Code	Description
96365	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366	Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Keppra (J1953) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

KEPPRA Medically Unlikely Edits (MUE)

The most billing units of J1953 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 3,000 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

KEPPRA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Myoclonic Seizures in Juvenile Myoclonic Epilepsy Myoclonic Seizures in Patients with Juvenile Myoclonic Epilepsy Partial-Onset Seizures Primary Generalized Tonic-Clonic Seizures

Drug Class

Decreased Central Nervous System Disorganized Electrical Activity [PE]

Frequently Asked Questions

Is there an available Keppra billing and coding guide?

We have not yet identified a manufacturer source of Keppra billing and coding information.

Are there any available Keppra patient assistance programs?

Our team did not identify a source for Keppra patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Keppra prescribing information?

KEPPRA prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Keppra side effect information?

Our team has not yet identified a source of side effects information for KEPPRA. Please check back in a few weeks.

Does billing KEPPRA require JZ/JW wastage modifiers?

CMS has identified KEPPRA(J1953) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

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