HYLENEX J Code: J3473

Drug & Product Overview

HCPCS Descriptor Injection, hyaluronidase, recombinant, 1 usp unit

HCPCS Added Date January 1, 2007

Manufacturer Antares Pharma

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About HYLENEX

Hylenex is a medication aligned to the HCPCS J Code: J3473 for billing, pricing, and reimbursement purposes in the United States. Classified under Misc., it is administered via the subcutaneous route and manufactured by Antares Pharma.

According to CMS Drug Use Information: Drug uses not available

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
18657-0117-04	HYLENEX Recombinant	Antares Pharma, Inc.	600	HYLENEX Recombinant Su bcutaneous Injec… Login for More

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HYLENEX Pricing & Reimbursement

J3473 Private Payer Reimbursement

$0.52 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

HYLENEX CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

JW / JZ modifiers apply

CMS has identified Hylenex (J3473) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

HYLENEX Medically Unlikely Edits (MUE)

The most billing units of J3473 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 usp unit.

Practitioner Office & Hospital Outpatient

450 units / day

= 450 usp unit per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

HYLENEX Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

it’s an adjuvant for subcutaneous fluid administration for hydration, to increase dispersion/absorption of injected drugs, and as an adjunct in subcutaneous urography

Drug Class

Endoglycosidase [EPC]Glycoside Hydrolases [CS]

Frequently Asked Questions

Is there an available Hylenex billing and coding guide?

We have not yet identified a manufacturer source of Hylenex billing and coding information.

Are there any available Hylenex patient assistance programs?

Our team did not identify a source for Hylenex patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Hylenex prescribing information?

HYLENEX prescribing information can be found at the link below: Visit Here →

Where can I find Hylenex side effect information?

Our team has not yet identified a source of side effects information for HYLENEX. Please check back in a few weeks.

Does billing HYLENEX require JZ/JW wastage modifiers?

CMS has identified HYLENEX(J3473) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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