HEPZATO J Code: J9248

Drug & Product Overview

HCPCS Descriptor Injection, melphalan (hepzato), 1 mg

HCPCS Added Date April 1, 2024

Manufacturer Delcath Systems

Route of Administration Intra-Arterial

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Kit

About HEPZATO

Hepzato is a medication aligned to the HCPCS J Code: J9248 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology, it is administered via the intra-arterial route and manufactured by Delcath Systems.

According to CMS Drug Use Information: This medication is used to treat serious liver problems (liver metastases) that may occur with some types of skin cancer. Melphalan belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
75833-0601-01	Hepzato Kit	Delcath Systems, Inc.	250	Kit
75833-0601-02	Hepzato Kit	Delcath Systems, Inc.	250	Kit

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HEPZATO Pricing & Reimbursement

J9248 Private Payer Reimbursement

$825.00 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

Melphalan Hydrochloride Injection, Powder, Lyophilized, For Solution 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J9248	Delcath Systems	Melphalan Hydrochloride Injection, Powder, Lyophilized, For Solution	Injection, melphalan (hepzato), 1 mg

HEPZATO CPT Administration Codes

CPT Code	Description
96409	Chemotherapy administration; intravenous, push technique, single or initial substance/drug
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415 Login for More	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure) Login for More

JW / JZ modifiers apply

CMS has identified Hepzato (J9248) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

HEPZATO Medically Unlikely Edits (MUE)

The most billing units of J9248 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

250 units / day

= 250 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

HEPZATO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Uveal melanoma with unresectable hepatic metastases

Frequently Asked Questions

Is there an available HEPZATO billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for HEPZATO.

Are there any available HEPZATO patient assistance programs?

HEPZATO patient assistance information can be found through Delcath. Visit Here →

Where can I find Melphalan (Apotex) prescribing information?

HEPZATO prescribing information can be found at the link below: Visit Here →

Where can I find HEPZATO side effect information?

Our team has not yet identified a source of side effect information for HEPZATO.

Does billing HEPZATO require JZ/JW wastage modifiers?

CMS has identified HEPZATO(J9248) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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