GIVLAARI J Code: J0223

Drug & Product Overview

HCPCS Descriptor Injection, givosiran, 0.5 mg

HCPCS Added Date July 1, 2020

Manufacturer Alnylam Pharmaceuticals

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About GIVLAARI

Givlaari is a medication aligned to the HCPCS J Code: J0223 for billing, pricing, and reimbursement purposes in the United States. It is a Genetic Disorder drug administered via the subcutaneous route and manufactured by Alnylam Pharmaceuticals.

According to CMS Drug Use Information: Givosiran is used to treat a certain inherited disorder (acute hepatic porphyria). This disorder causes a buildup of certain chemicals (porphyrins) in the body which can lead to liver and nerve problems. Givosiran works by reducing the amount of porphyrins in the body.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
71336-1001-01	Givlaari	Alnylam Pharmaceuticals, Inc.	378	189 MG / 1 ML

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GIVLAARI Pricing & Reimbursement

J0223 Private Payer Reimbursement

$120.52 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

GIVLAARI CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

JW / JZ modifiers apply

CMS has identified Givlaari (J0223) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

GIVLAARI Medically Unlikely Edits (MUE)

The most billing units of J0223 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.5 mg.

Practitioner Office & Hospital Outpatient

756 units / day

= 378 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

GIVLAARI Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Hepatic Porphyria

Drug Class

Aminolevulinate Synthase 1-directed RNA Interaction [EPC]Decreased RNA Integrity [PE]RNASmall Interfering [CS]Small Interfering RNA [EPC]

Frequently Asked Questions

Is there an available Givlaari billing and coding guide?

Billing and coding information for GIVLAARI can be found through Alnylam Pharmaceuticals, Inc.. Visit Here →

Are there any available Givlaari patient assistance programs?

GIVLAARI patient assistance information can be found through Alnylam Pharmaceuticals, Inc.. Visit Here →

Where can I find Givlaari prescribing information?

GIVLAARI prescribing information can be found at the link below: Visit Here →

Where can I find Givlaari side effect information?

Our team has not yet identified a source of side effects information for GIVLAARI. Please check back in a few weeks.

Does billing GIVLAARI require JZ/JW wastage modifiers?

CMS has identified GIVLAARI(J0223) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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