CRYSVITA J Code: J0584

Drug & Product Overview

HCPCS Descriptor Injection, burosumab-twza 1 mg

HCPCS Added Date January 1, 2019

Manufacturer Kyowa Kirin

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About CRYSVITA

Crysvita is a medication aligned to the HCPCS J Code: J0584 for billing, pricing, and reimbursement purposes in the United States. Classified under Genetic Disorder, it is administered via the subcutaneous route and manufactured by Kyowa Kirin.

According to CMS Drug Use Information: This medication is used to treat low phosphate levels caused by a certain rare genetic problem (X-linked hypophosphatemia) or by a tumor (tumor-induced osteomalacia). It helps by reducing a hormone in your blood (fibroblast growth factor 23) which increases phosphate levels in your body. Normal phosphate levels are important for the growth and strength of bones, teeth, and muscles. Burosumab belongs to a class of drugs known as monoclonal antibodies.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
42747-0102-01	Crysvita	Kyowa Kirin, Inc.	10	10 MG / 1 ML
42747-0203-01	Crysvita	Kyowa Kirin, Inc.	20	20 MG / 1 ML
42747-0304-01	Crysvita	Kyowa Kirin, Inc.	30	30 MG / 1 ML

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CRYSVITA Pricing & Reimbursement

J0584 Private Payer Reimbursement

$498.02 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

CRYSVITA CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

JW / JZ modifiers apply

CMS has identified Crysvita (J0584) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

CRYSVITA Medically Unlikely Edits (MUE)

The most billing units of J0584 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

90 units / day

= 90 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

CRYSVITA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

FGF23-related hypophosphatemia in tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors that cannot be curatively resected or localized X-linked hypophosphatemia

Frequently Asked Questions

Is there an available Crysvita billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for CRYSVITA.

Are there any available Crysvita patient assistance programs?

CRYSVITA patient assistance information can be found through Kyowa Kirin. Visit Here →

Where can I find Crysvita prescribing information?

CRYSVITA prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Crysvita side effect information?

Our team has not yet identified a source of side effects information for CRYSVITA. Please check back in a few weeks.

Does billing CRYSVITA require JZ/JW wastage modifiers?

CMS has identified CRYSVITA(J0584) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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