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Updated July 1st, 2026

ARANESP J Code: J0881

Injection, darbepoetin alfa, 1 microgram (non-esrd use)

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Q4 2026 Medicare Payment Limit for J0881, effective October 1, 2026: $3.081 per HCPCS billing unit, up 5.5% from $2.92. From CMS's final file.

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Medicare Payment Limit ?
$2.92
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$2.92
/ HCPCS billing unit · APC 1685
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
25
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Drug & Product Overview

HCPCS Descriptor Injection, darbepoetin alfa, 1 microgram (non-esrd use)
HCPCS Added Date January 1, 2006
Manufacturer Amgen
Route of Administration Intravenous, Subcutaneous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Solution | Solution

About ARANESP

Aranesp is a medication aligned to the HCPCS J Code: J0881 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology Colony Stimulating Factor, it is administered via the intravenous or subcutaneous routes and manufactured by Amgen.

According to CMS Drug Use Information: This medication is used to treat anemia (low red blood cell count) in people with long-term serious kidney disease (chronic kidney failure) and people receiving chemotherapy for some types of cancer (cancer that does not involve the bone marrow or blood cells). Darbepoetin alfa also helps to reduce the need for blood transfusions. It works by signaling the bone marrow to make more red blood cells. This medication is very similar to the natural substance in your body (erythropoietin) that prevents anemia.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 25 NDCs — log in for the full crosswalk.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
55513-0002-04 Aranesp Amgen, Inc 100 25 MCG / 1 ML
55513-0003-04 Aranesp Amgen, Inc 160 40 MCG / 1 ML
55513-0004-04 Aranesp Amgen, Inc 240 60 MCG / 1 ML
55513-0005-04 Aranesp Amgen, Inc 400 100 MCG / 1 ML
55513-0006-01 Aranesp Amgen, Inc 200 200 MCG / 1 ML
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ARANESP Pricing & Reimbursement

J0881 Private Payer Reimbursement
$3.09 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

ARANESP CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96372 Login for More Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular Login for More
JW / JZ modifiers apply

CMS has identified Aranesp (J0881) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

ARANESP Medically Unlikely Edits (MUE)

The most billing units of J0881 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mcg.

Practitioner Office & Hospital Outpatient
500 units / day
= 500 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mcg Enter a dose to see how many billing units it is and whether it is under the limit.

ARANESP Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Anemia Due to Chemotherapy in Patients with Cancer Anemia Due to Chronic Kidney Disease
Drug Class
Erythropoiesis-stimulating Agent [EPC]Erythropoietin [CS]Increased Erythroid Cell Production [PE]

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Frequently Asked Questions

Is there an available Aranesp billing and coding guide?
Our team has not identified a manufacturer-published source of billing and coding information for ARANESP.
Are there any available Aranesp patient assistance programs?
ARANESP patient assistance information can be found through Amgen. Visit Here →
Where can I find Aranesp prescribing information?
ARANESP prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Aranesp side effect information?
Our team has not yet identified a source of side effects information for ARANESP. Please check back in a few weeks.
Does billing ARANESP require JZ/JW wastage modifiers?
CMS has identified ARANESP(J0881) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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J0882ARANESPInjection, darbepoetin alfa, 1 microgram (for esrd on dialysis)AmgenAdded January 1, 2006J0885EPOGENInjection, epoetin alfa, (for non-esrd use), 1000 unitsAmgenAdded January 1, 2006Q4081EPOGENInjection, epoetin alfa, 100 units (for esrd on dialysis)AmgenAdded January 1, 2007Q5105RETACRITInjection, epoetin alfa-epbx, biosimilar, (retacrit) (for esrd on dialysis), 100 unitsVifor InternationalAdded July 1, 2018Q5106RETACRITInjection, epoetin alfa-epbx, biosimilar, (retacrit) (for non-esrd use), 1000 unitsVifor InternationalAdded July 1, 2018J0901VAFSEOVadadustat, oral, 1 mg (for esrd on dialysis)Akebia TherapeuticsAdded January 1, 2025J0887MIRCERAInjection, epoetin beta, 1 microgram, (for esrd on dialysis)Vifor InternationalAdded January 1, 2015J0888MIRCERAInjection, epoetin beta, 1 microgram, (for non esrd use)Vifor InternationalAdded January 1, 2015J1442NEUPOGENInjection, filgrastim (g-csf), excludes biosimilars, 1 microgramAmgenAdded January 1, 2014J1447GRANIXInjection, tbo-filgrastim, 1 microgramTevaAdded January 1, 2016