ZYCUBO
copper histidinate · Sentynl Therapeutics
Drug & Product Overview
How to Bill ZYCUBO Now
Through December 31, 2026, bill ZYCUBO with J3490, the code for unclassified drugs, and identify the product by its NDC. From January 1, 2027, bill J7293.
Check coverage before you bill
ZYCUBO’s label allows a trained caregiver to give it at home. CMS’s descriptor for J7293 reads “Injection, copper histidinate, 0.01 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)”, so Medicare accepts the code only for doses given under a physician’s direct supervision. Doses given at home are usually billed on the pharmacy benefit instead. See the SAD exclusion lists →
| Setting | Claim Form | Billing Code | Notes |
|---|---|---|---|
| Physician office / Part B | CMS-1500 / 837P | J3490 | Only for doses given under a physician’s direct supervision. Enter the drug name, dose and NDC in Item 19 (or the 837P equivalent). |
| Hospital outpatient (OPPS) | UB-04 / 837I | C9399 | Unclassified drug or biological. Separately payable and priced manually by the MAC. |
About ZYCUBO
ZYCUBO (copper histidinate) is a subcutaneous injection from Sentynl Therapeutics for Menkes disease in pediatric patients. It was approved by the FDA on January 12, 2026.
ZYCUBO Pricing & NDCs
Package WAC and AWP for each NDC, updated monthly. There's no ASP payment limit until a permanent code takes effect.
| NDC Code | Package | WAC | AWP |
|---|---|---|---|
| •••••-••••-•• | ••• MG single-dose vial | $•••.•• | $•••.•• |
1 NDC on file. Subscribe to see its package, WAC and AWP, with monthly history.
HCPCS Code Status
As of Nov 5, 2026J3490 claims for ZYCUBO with dates of service on or after January 1, 2027 will be denied. Confirm coding with your payer before billing.
ZYCUBO Clinical Information
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Frequently Asked Questions
What HCPCS code is used for ZYCUBO?
J3490 (unclassified drugs) for dates of service through December 31, 2026, and its permanent code J7293 from January 1, 2027, for doses given under a physician’s direct supervision. Hospital outpatient claims use C9399 until the permanent code takes effect.
Can J7293 be billed when a caregiver gives ZYCUBO at home?
Not to Medicare. CMS’s descriptor says the code is not for use when the drug is self-administered. Home doses are usually billed on the pharmacy benefit.
What NDC goes on a ZYCUBO claim?
The NDC of the package you administered. Subscribers can see ZYCUBO’s NDCs with package, WAC and AWP.