VYXEOS J Code: J9153

Drug & Product Overview

HCPCS Descriptor Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine

HCPCS Added Date January 1, 2019

Manufacturer Jazz Pharmaceuticals

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Suspension

About VYXEOS

Vyxeos is a medication aligned to the HCPCS J Code: J9153 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by Jazz Pharmaceuticals.

According to CMS Drug Use Information: This medication is a combination product of daunorubicin and cytarabine liposome and is used to treat leukemia. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 2 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
68727-0745-02	Vyxeos	Jazz Pharmaceuticals, Inc.	88	100 MG / 20 ML
•••••-••••-•• Log in to view	VYXEOS

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VYXEOS Pricing & Reimbursement

J9153 Private Payer Reimbursement

$269.06 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

(daunorubicin And Cytarabine) Liposome 505(b)(2) Information:

HCPCS Code	Manufacturer	Active Ingredient	HCPCS Description
J9153	Jazz Pharmaceuticals	(daunorubicin And Cytarabine) Liposome	Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine

VYXEOS Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 75%

Avg. Days to File 4.6days

Avg. Days to Pay 28.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9153 claims analytics on FocalPoint →

VYXEOS CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Vyxeos (J9153) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

VYXEOS Medically Unlikely Edits (MUE)

The most billing units of J9153 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg/2.27 mg.

Practitioner Office & Hospital Outpatient

132 units / day

= 132 mg/2.27 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

VYXEOS Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Therapy-related acute myeloid leukemia (t-AML) Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC)

Drug Class

Anthracycline Topoisomerase Inhibitor [EPC]Anthracyclines [CS]Nucleic Acid Synthesis Inhibitors [MoA]Nucleoside Metabolic Inhibitor [EPC]Topoisomerase Inhibitors [MoA]

Frequently Asked Questions

Is there an available Vyxeos billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for VYXEOS.

Are there any available Vyxeos patient assistance programs?

VYXEOS patient assistance information can be found through Jazz Pharmaceuticals. Visit Here →

Where can I find Vyxeos prescribing information?

VYXEOS prescribing information can be found at the link below: Visit Here →

Where can I find Vyxeos side effect information?

Information regarding VYXEOS's side effects can be found at MedlinePlus Visit Here →

Does billing VYXEOS require JZ/JW wastage modifiers?

CMS has identified VYXEOS(J9153) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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