Home › Drug Codes › J Codes › J2860 · SYLVANT
Updated July 1st, 2026

SYLVANT J Code: J2860

Injection, siltuximab, 10 mg

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Q4 2026 Medicare Payment Limit for J2860, effective October 1, 2026: $178.427 per HCPCS billing unit, up 2.5% from $174.066. From CMS's final file.

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Medicare Payment Limit ?
$174.066
/ HCPCS billing unit · Q3 2026
APC Payment Limit ?
$174.066
/ HCPCS billing unit · APC 9455
ASP ?
$•••.••
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WAC · AWP ?
$•••.••
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NDCs Crosswalked ?
2
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Drug & Product Overview

HCPCS Descriptor Injection, siltuximab, 10 mg
HCPCS Added Date January 1, 2016
Manufacturer Recordati Rare Diseases
Route of Administration Intravenous
Generic Status Single-Source; Branded
Dosage Type Single-Dose
Dosage Form Injection, Powder, For Solution

About SYLVANT

Sylvant is a medication aligned to the HCPCS J Code: J2860 for billing, pricing, and reimbursement purposes in the United States. It is an Anti-HIV drug administered via the intravenous route and manufactured by Recordati Rare Diseases.

According to CMS Drug Use Information: Siltuximab is used to treat a certain rare illness (multicentric Castleman's disease - MCD) if you do not have HIV or herpes infections. Siltuximab blocks a certain natural substance that affects the immune system. Siltuximab can improve the symptoms of MCD including lumps under the skin, fever, weakness or tiredness, or night sweats.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code Drug Manufacturer Billing Units / Pkg Package Size
73090-0420-01 Sylvant Recordati Rare Diseases, Inc. 10 100 MG
73090-0421-01 Sylvant Recordati Rare Diseases, Inc. 40 400 MG
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SYLVANT Pricing & Reimbursement

J2860 Private Payer Reimbursement
$168.51 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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UnitedHealthcare, BlueCross BlueShield, Aetna, Cigna

Historical Graphing and Billing Calculator

per HCPCS unit
As of Q3 2026

SYLVANT Claims Performance

Claims from Jan 2026 – Aug 2026
Claim Denial Rate 24.44%
Avg. Days to File 8.7days
Avg. Days to Pay 30.6days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J2860 claims analytics on FocalPoint →
OnPoint Oncology

SYLVANT CPT Administration Codes

The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.

CPT Code Description
96413 Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415 Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)
JW / JZ modifiers apply

CMS has identified Sylvant (J2860) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

SYLVANT Medically Unlikely Edits (MUE)

The most billing units of J2860 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 10 mg.

Practitioner Office & Hospital Outpatient
170 units / day
= 1,700 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

mg Enter a dose to see how many billing units it is and whether it is under the limit.

SYLVANT Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Multicentric Castleman's Disease (MCD)
Drug Class
Interleukin-6 Antagonist [EPC]Interleukin-6 Antagonists [MoA]

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Frequently Asked Questions

Is there an available Sylvant billing and coding guide?
Billing and coding information for SYLVANT can be found through Recordati Rare Diseases. Visit Here →
Are there any available Sylvant patient assistance programs?
SYLVANT patient assistance information can be found through Recordati Rare Diseases. Visit Here →
Where can I find Sylvant prescribing information?
SYLVANT prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →
Where can I find Sylvant side effect information?
Our team has not yet identified a source of side effects information for SYLVANT. Please check back in a few weeks.
Does billing SYLVANT require JZ/JW wastage modifiers?
CMS has identified SYLVANT(J2860) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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