RYSTIGGO J Code: J9333

Drug & Product Overview

HCPCS Descriptor Injection, rozanolixizumab-noli, 1 mg

HCPCS Added Date January 1, 2024

Manufacturer UCB Pharma

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About RYSTIGGO

Rystiggo is a medication aligned to the HCPCS J Code: J9333 for billing, pricing, and reimbursement purposes in the United States. This Neurology medication is administered via the subcutaneous route and manufactured by UCB Pharma.

According to CMS Drug Use Information: Rozanolixizumab is used to treat a certain muscle condition (generalized myasthenia gravis). It may help to improve symptoms of muscle weakness.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
50474-0980-79	Rystiggo	UCB, Inc.	280	280 MG / 2 ML
50474-0981-83	Rystiggo	UCB, Inc.	420	420 MG / 3 ML
50474-0982-84	Rystiggo	UCB, Inc.	560	560 MG / 4 ML
50474-0983-86	Rystiggo	UCB, Inc.	840	840 MG / 6 ML

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RYSTIGGO Pricing & Reimbursement

J9333 Private Payer Reimbursement

$23.45 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

RYSTIGGO CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

JW / JZ modifiers apply

CMS has identified Rystiggo (J9333) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

RYSTIGGO Medically Unlikely Edits (MUE)

The most billing units of J9333 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

840 units / day

= 840 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

RYSTIGGO Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

generalized myasthenia gravis

Drug Class

Neonatal Fc Receptor Blocker [EPC]Neonatal Fc Receptor Blockers [MoA]

Frequently Asked Questions

Is there an available Rystiggo billing and coding guide?

Billing and coding information for RYSTIGGO can be found through UCB. Visit Here →

Are there any available Rystiggo patient assistance programs?

RYSTIGGO patient assistance information can be found through UCB. Visit Here →

Where can I find Rystiggo prescribing information?

RYSTIGGO prescribing information can be found at the link below: Visit Here →

Where can I find Rystiggo side effect information?

Information regarding RYSTIGGO's side effects can be found at MedlinePlus Visit Here →

Does billing RYSTIGGO require JZ/JW wastage modifiers?

CMS has identified RYSTIGGO(J9333) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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