Rylaze J Code: J9021

Drug & Product Overview

HCPCS Descriptor Injection, asparaginase, recombinant, (rylaze), 0.1 mg

HCPCS Added Date January 1, 2022

Manufacturer Jazz Pharmaceuticals

Route of Administration Intramuscular

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection

About Rylaze

Rylaze is a medication aligned to the HCPCS J Code: J9021 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intramuscular route and manufactured by Jazz Pharmaceuticals.

According to CMS Drug Use Information: This product is used to treat certain types of cancers (acute lymphoblastic leukemia-ALL, lymphoblastic lymphoma-LBL). Asparaginase erwinia chrysanthemi works by starving tumor cells of needed nutrients and slowing tumor cell growth.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 1 of 2 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
68727-0900-03	Rylaze	Jazz Pharmaceuticals, Inc.	300	10 MG / 0.5 ML
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Rylaze Pricing & Reimbursement

J9021 Private Payer Reimbursement

$58.07 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

Rylaze CPT Administration Codes

CPT Code	Description
96401	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic

JW / JZ modifiers apply

CMS has identified Rylaze (J9021) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

Rylaze Medically Unlikely Edits (MUE)

The most billing units of J9021 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.1 mg.

Practitioner Office & Hospital Outpatient

1,500 units / day

= 150 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

Rylaze Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LBL)

Drug Class

Asparaginase [CS]Asparagine-specific Enzyme [EPC]

Frequently Asked Questions

Is there an available Rylaze billing and coding guide?

Billing and coding information for Rylaze can be found through Jazz Pharmaceuticals. Visit Here →

Are there any available Rylaze patient assistance programs?

Rylaze patient assistance information can be found through Jazz Pharmaceuticals. Visit Here →

Where can I find Rylaze prescribing information?

Rylaze prescribing information can be found at the link below: Visit Here →

Where can I find Rylaze side effect information?

Information regarding Rylaze's side effects can be found at MedlinePlus Visit Here →

Does billing Rylaze require JZ/JW wastage modifiers?

CMS has identified Rylaze(J9021) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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