KEPIVANCE J Code: J2425

Drug & Product Overview

HCPCS Descriptor Injection, palifermin, 50 micrograms

HCPCS Added Date January 1, 2006

Manufacturer Sobi

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About KEPIVANCE

Kepivance is a medication aligned to the HCPCS J Code: J2425 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intravenous route and manufactured by Sobi.

According to CMS Drug Use Information: Palifermin is used by people with blood or bone marrow cancer (such as leukemia, multiple myeloma) who are receiving chemotherapy or radiation along with stem cell transplant. The chemotherapy or radiation can cause severe sores in the mouth and throat (mucositis). Palifermin is used to decrease the risk of these sores and to decrease the time it takes for these sores to heal. Palifermin may work by increasing the growth of cells in the mouth and throat. This medication should only be used by patients with blood or bone marrow cancer, and not by patients with other types of cancer.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 2 of 3 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
66658-0113-03	Kepivance	Swedish Orphan Biovitrum AB (publ)	310	5160 MCG / 1.2 ML
66658-0113-06	Kepivance	Swedish Orphan Biovitrum AB (PuBL)	620	5.16 MG
•••••-••••-•• Log in to view	KEPIVANCE

Login to view 1 more NDC package View pricing, complete NDC-to-HCPCS alignments, and package details.

Login →

KEPIVANCE Pricing & Reimbursement

J2425 Private Payer Reimbursement

$36.47 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

KEPIVANCE CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Kepivance (J2425) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

KEPIVANCE Medically Unlikely Edits (MUE)

The most billing units of J2425 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 50 mcg.

Practitioner Office & Hospital Outpatient

125 units / day

= 6,250 mcg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

KEPIVANCE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

severe oral mucositis in hematologic malignancies receiving myelotoxic therapy with autologous hematopoietic stem cell support

Drug Class

Fibroblast Growth Factor 7 [CS]Increased Epithelial Proliferation [PE]Mucocutaneous Epithelial Cell Growth Factor [EPC]

Frequently Asked Questions

Is there an available Kepivance billing and coding guide?

We have not yet identified a manufacturer source of Kepivance billing and coding information.

Are there any available Kepivance patient assistance programs?

Our team did not identify a source for Kepivance patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Kepivance prescribing information?

KEPIVANCE prescribing information can be found at the link below: Visit Here →

Where can I find Kepivance side effect information?

Information regarding KEPIVANCE's side effects can be found at MedlinePlus Visit Here →

Does billing KEPIVANCE require JZ/JW wastage modifiers?

CMS has identified KEPIVANCE(J2425) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.