INVEGA TRINZA J Code: J2427

Drug & Product Overview

HCPCS Descriptor Injection, paliperidone palmitate extended release (invega hafyera, or invega trinza), 1 mg

HCPCS Added Date July 1, 2023

Manufacturer Janssen

Route of Administration Intramuscular

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Suspension, Extended Release

About INVEGA TRINZA

Invega Trinza is a medication aligned to the HCPCS J Code: J2427 for billing, pricing, and reimbursement purposes in the United States. This Psychiatric medication is administered via the intramuscular route and manufactured by Janssen.

According to CMS Drug Use Information: This medication is used to treat a certain mental/mood disorder (schizophrenia). Paliperidone belongs to a class of drugs known as atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain. This long-acting form of paliperidone is used only after you have received treatment with either the monthly injectable form of this drug for at least 4 months, or the every-3-month injectable form for at least 3 months.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 6 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
50458-0606-01	Invega Trinza	Janssen Pharmaceuticals, Inc	273	273 MG / 0.88 ML
50458-0607-01	Invega Trinza	Janssen Pharmaceuticals, Inc	410	410 MG / 1.32 ML
50458-0608-01	Invega Trinza	Janssen Pharmaceuticals, Inc	546	546 MG / 1.75 ML
50458-0609-01	Invega Trinza	Janssen Pharmaceuticals, Inc	819	819 MG / 2.63 ML
50458-0611-01	Invega Hafyera	Janssen Pharmaceuticals, Inc	1092	1092 MG / 3.5 ML
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INVEGA TRINZA Pricing & Reimbursement

J2427 Private Payer Reimbursement

$12.80 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

INVEGA TRINZA CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

Not on the CMS JW / JZ list

CMS does not include Invega Trinza (J2427) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2427. Wastage billing guide →

INVEGA TRINZA Medically Unlikely Edits (MUE)

The most billing units of J2427 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1mg.

Practitioner Office & Hospital Outpatient

1,560 units / day

= 1,560 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

INVEGA TRINZA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Schizophrenia

Drug Class

Atypical Antipsychotic [EPC]

Frequently Asked Questions

Is there an available Invega Trinza billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for INVEGA TRINZA.

Are there any available Invega Trinza patient assistance programs?

INVEGA TRINZA patient assistance information can be found through JANSSEN PHARMACEUTICALS, INC.. Visit Here →

Where can I find Invega Trinza prescribing information?

INVEGA TRINZA prescribing information can be found at the link below: Visit Here →

Where can I find Invega Trinza side effect information?

Information regarding INVEGA TRINZA's side effects can be found at MedlinePlus Visit Here →

Does billing INVEGA TRINZA require JZ/JW wastage modifiers?

CMS does not include INVEGA TRINZA (J2427) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J2427. For more information, visit the link below.

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