IMLYGIC J Code: J9325

Drug & Product Overview

HCPCS Descriptor Injection, talimogene laherparepvec, per 1 million plaque forming units

HCPCS Added Date January 1, 2017

Manufacturer Amgen

Route of Administration Intralesional

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Suspension

About IMLYGIC

Imlygic is a medication aligned to the HCPCS J Code: J9325 for billing, pricing, and reimbursement purposes in the United States. It is an Oncology drug administered via the intralesional route and manufactured by Amgen.

According to CMS Drug Use Information: This medication is used to treat a certain type of skin cancer (melanoma). It contains a live virus (cold sore virus) that has been weakened. Talimogene laherparepvec infects the cancer cells and works by slowing or stopping their growth.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
55513-0078-01	Imlygic	Amgen Inc	1	Imlygic Intralesional Injection 100000… Login for More
55513-0079-01	Imlygic	Amgen Inc	100	Imlygic Intralesional Injection 100000… Login for More

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IMLYGIC Pricing & Reimbursement

J9325 Private Payer Reimbursement

$76.49 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

IMLYGIC CPT Administration Codes

CPT Code	Description
11980	Subcutaneous hormone pellet implantation

JW / JZ modifiers apply

CMS has identified Imlygic (J9325) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

IMLYGIC Medically Unlikely Edits (MUE)

The most billing units of J9325 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 million pfu.

Practitioner Office & Hospital Outpatient

400 units / day

= 400 million pfu per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

IMLYGIC Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Melanoma

Frequently Asked Questions

Is there an available Imlygic billing and coding guide?

Billing and coding information for IMLYGIC can be found through Amgen. Visit Here →

Are there any available Imlygic patient assistance programs?

IMLYGIC patient assistance information can be found through Amgen. Visit Here →

Where can I find Imlygic prescribing information?

IMLYGIC prescribing information can be found at the link below: Visit Here →

Where can I find Imlygic side effect information?

Information regarding IMLYGIC's side effects can be found at MedlinePlus Visit Here →

Does billing IMLYGIC require JZ/JW wastage modifiers?

CMS has identified IMLYGIC(J9325) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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