Heads up: this issue is from May 22, 2025. Because it covers time-sensitive coding and regulatory topics, some details may have changed since. See the latest issues for current guidance.
Here are the ACCEPTED HCPCS drug changes for dates of service on or after July 1, 2025.. For all these projected HCPCS DRUG changes, see Buyandbill.com. for an easy-to-read version of this.
Added Codes
HCPCS Long Descriptor
C9174 Injection, datopotamab deruxtecan-dlnk, 1 mg
C9175 Injection, treosulfan, 50 mg
J0165 Injection, epinephrine, not otherwise specified, 0.1 mg
J0166 Injection, epinephrine (bpi), not therapeutically equivalent to j0165, 0.1 mg
J0167 Injection, epinephrine (hospira), not therapeutically equivalent to j0165, 0.1 mg
J0168 Injection, epinephrine (international medication systems), not therapeutically equivalent to j0165, 0.1 mg
J0169 Injection, epinephrine (adrenalin), not therapeutically equivalent to j0165, 0.1 mg
J0616 Injection, metoprolol tartrate, 1 mg
J0618 Injection, calcium chloride, 2 mg
J1163 Injection, diltiazem hydrochloride, 0.5 mg
J1326 Injection, zolbetuximab-clzb, 2 mg
J2312 Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
J2313 Injection, naloxone hydrochloride (zimhi), 0.01 mg
J3373 Injection, vancomycin hydrochloride, 10 mg
J3374 Injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg
J3375 Injection, vancomycin hydrochloride (xellia), not therapeutically equivalent to j3373, 10 mg
J3391 Injection, atidarsagene autotemcel, per treatment
J7172 Injection, marstacimab-hncq, 0.5 mg
J7356 Injection, foscarbidopa 0.25 mg/foslevodopa 5 mg
J9174 Injection, docetaxel (beizray), 1 mg
J9220 Injection, indigotindisulfonate sodium, 1 mg
J9275 Injection, cosibelimab-ipdl, 2 mg
J9276 Injection, zanidatamab-hrii, 2 mg
J9289 Injection, nivolumab, 2 mg and hyaluronidase-nvhy
J9341 Injection, thiotepa (tepylute), 1 mg
J9342 Injection, thiotepa, not otherwise specified, 1 mg
J9382 Injection, zenocutuzumab-zbco, 1 mg
Q2058 Obecabtagene autoleucel, 10 up to 400 million cd19 car-positive viable t cells, including leukapheresis and dose preparation procedures, per infusion
Q4382 Advograft dual, per square centimeter
Q5098 Injection, ustekinumab-srlf (imuldosa), biosimilar, 1 mg
Q5099 Injection, ustekinumab-stba (steqeyma), biosimilar, 1 mg
Q5100 Injection, ustekinumab-kfce (yesintek), biosimilar, 1 mg
Q5153 Injection, aflibercept-yszy (opuviz), biosimilar, 1 mg
Coverage Change (No idea what it is )
HCPCS. Long Descriptor
J0475 Injection, baclofen, 10 mg
J1950 Injection, leuprolide acetate (for depot suspension), per 3.75 mg
J9065 Injection, cladribine, per 1 mg
Discontinued Codes
HCPCS. Long Descriptor
C9173 Injection, filgrastim-txid (nypozi), biosimilar, 1 microgram
C9300 Injection, indigotindisulfonate sodium, 1 mg
C9301 Obecabtagene autoleucel, up to 400 million cd19 car-positive viable t cells, including leukapheresis and dose preparation procedures, per therapeutic dose
C9302 Injection, zanidatamab-hrii, 2 mg
C9303 Injection, zolbetuximab-clzb, 1 mg
C9304 Injection, marstacimab-hncq, 0.5 mg
J0171 Injection, adrenalin, epinephrine, 0.1 mg
J0173 Injection, epinephrine (belcher), not therapeutically equivalent to j0171, 0.1 mg
J2310 Injection, naloxone hydrochloride, per 1 mg
J2311 Injection, naloxone hydrochloride (zimhi), 1 mg
J3370 Injection, vancomycin hcl, 500 mg
J3371 Injection, vancomycin hcl (mylan), not therapeutically equivalent to j3370, 500 mg
J3372 Injection, vancomycin hcl (xellia), not therapeutically equivalent to j3370, 500 mg
J9340 Injection, thiotepa, 15 mg
M0248 Intravenous infusion, sotrovimab, includes infusion and post administration monitoring in the home or residence; this includes a beneficiary's home that has been made provider-based to the hospital during the covid-19 public health emergency
Descriptor Change
J1954 Injection, leuprolide acetate for depot suspension (lutrate depot), 7.5 mg
J9292 Injection, pemetrexed dipotassium, 10 mg
Q9998 Injection, ustekinumab-aekn (selarsdi), biosimilar, 1 mg
For a complete list, see the HCPCS Quarterly Update
