EPKINLY J Code: J9321

Drug & Product Overview

HCPCS Descriptor Injection, epcoritamab-bysp, 0.16 mg

HCPCS Added Date January 1, 2024

Manufacturer Genmab

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About EPKINLY

Epkinly is a medication aligned to the HCPCS J Code: J9321 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the subcutaneous route and manufactured by Genmab.

According to CMS Drug Use Information: This medication is used to treat certain types of cancer (diffuse large B-cell lymphoma-DLBCL, high-grade B-cell lymphoma, follicular lymphoma). Epcoritamab works by slowing or stopping the growth of cancer cells.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
82705-0002-01	Epkinly	Genmab US, Inc.	25	4 MG / 0.8 ML
82705-0010-01	Epkinly	Genmab US, Inc.	300	48 MG / 0.8 ML

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EPKINLY Pricing & Reimbursement

J9321 Private Payer Reimbursement

$58.50 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q4 2026

EPKINLY Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 10.5%

Avg. Days to File 6.4days

Avg. Days to Pay 24.5days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J9321 claims analytics on FocalPoint →

EPKINLY CPT Administration Codes

CPT Code	Description
96401	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal anti-neoplastic

JW / JZ modifiers apply

CMS has identified Epkinly (J9321) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

EPKINLY Medically Unlikely Edits (MUE)

The most billing units of J9321 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.16 mg.

Practitioner Office & Hospital Outpatient

300 units / day

= 48 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

EPKINLY Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Diffuse large B-cell lymphoma (DLBCL) or High-grade B-cell lymphoma Follicular Lymphoma

Drug Class

Bispecific CD20-directed CD3 T Cell Engager [EPC]CD20-directed Antibody Interactions [MoA]CD3 Receptor Agonists [MoA]CD3-directed Antibody Interactions [MoA]Cytochrome P450 Inhibitors [MoA]Increased Cytokine Activity [PE]

Frequently Asked Questions

Is there an available Epkinly billing and coding guide?

Billing and coding information for EPKINLY can be found through GENMAB US, INC.. Visit Here →

Are there any available Epkinly patient assistance programs?

EPKINLY patient assistance information can be found through GENMAB US, INC.. Visit Here →

Where can I find Epkinly prescribing information?

EPKINLY prescribing information can be found at the link below: Visit Here →

Where can I find Epkinly side effect information?

Information regarding EPKINLY's side effects can be found at MedlinePlus Visit Here →

Does billing EPKINLY require JZ/JW wastage modifiers?

CMS has identified EPKINLY(J9321) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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