CPT Administration Code: 81235 | EGFR Gene Analysis

Code Overview

CPT® administration code details for 81235.

CPT Code Descriptor EGFR (epidermal growth factor receptor) (eg, non-small cell lung cancer) gene analysis, common variants (eg, exon 19 LREA deletion, L858R, T790M, G719A, G719S, L861Q)

Code Category Egfr Gene Analysis

Route / Technique Not Applicable (Laboratory Test)

Code Type Initial / Primary Code

About Egfr Gene Analysis – 81235

81235 is a CPT administration code for egfr gene analysis. The description for 81235: EGFR (epidermal growth factor receptor) (eg, non-small cell lung cancer) gene analysis, common variants (eg, exon 19 LREA deletion, L858R, T790M, G719A, G719S, L861Q).

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81235 RVU Breakdown & Medicare Reimbursement

Based on the CY 2026 CMS Physician Fee Schedule. National payment amounts, before geographic (GPCI) adjustment.

Component	Facility	Non-Facility
Work RVU — physician work	0.00	0.00
Practice Expense RVU — staff, supplies, equipment	0.00	0.00
Malpractice RVU — professional liability	0.00	0.00
Total RVUs	0.00	0.00
Medicare Payment — Total RVUs × $33.4009 CF	$0.00	$0.00

CY 2026 Medicare Conversion Factor: $33.4009. Facility and non-facility practice-expense RVUs are equal for this code.

81235 Locality-Adjusted Rates

Medicare payment varies by locality via GPCI adjustment. Log in to view rates for all 100+ Medicare localities.

Medicare Locality	Facility	Non-Facility
National (unadjusted)	$0.00	$0.00
Los Angeles–Long Beach, CA
Manhattan, NY
Houston, TX
Miami, FL

Related Administration Codes

The laboratory test code family. Report one initial code per encounter; add-on codes are listed separately in addition to the primary procedure.

CPT Code	Description	Type
80076	Hepatic function panel test in which the blood levels of protein, albumin, alkaline phosphatase, bilirubin, and liver enzymes are measured	Initial
81235This page	EGFR (epidermal growth factor receptor) (eg, non-small cell lung cancer) gene analysis, common variants (eg, exon 19 LREA deletion, L858R, T790M, G719A, G719S, L861Q)	Initial

Drugs Commonly Billed with 81235

HCPCS-coded drugs frequently administered under this CPT code. The list below is not exhaustive.

HCPCS Code	Drug	HCPCS Descriptor
J8565	IRESSA	Gefitinib, oral, 250 mg

Frequently Asked Questions

What are CPT Administration Codes?

CPT administration codes cover the work of giving a drug to a patient, such as an injection or an infusion. The drug itself is billed with its HCPCS J-code, and the administration is billed with a CPT code. Both go on the same claim. Learn More →

What is the Medicare Conversion Factor?

The conversion factor is the dollar amount CMS uses to turn a code's total RVUs into a Medicare payment. This page uses the CY 2026 conversion factor of $33.4009. CMS updates it every year in the Physician Fee Schedule final rule.

Facility vs. Non-Facility?

The non-facility rate applies in a physician office, where the practice pays for its own staff, supplies, and equipment, so the rate is usually higher. The facility rate applies in hospital outpatient departments and ASCs, where the facility bills for those costs separately.

How do I decide which administration code to use?

Pick the code that matches the type of drug, the route, and how long the administration takes. Start from the highest-ranking service you performed, then add the appropriate add-on codes for extra time or extra drugs. Manufacturer billing and coding guides often list suggested administration codes.

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CPT Administration Code: 81235 – Egfr Gene Analysis