COSELA J Code: J1448

Drug & Product Overview

HCPCS Descriptor Injection, trilaciclib, 1mg

HCPCS Added Date October 1, 2021

Manufacturer Pharmacosmos

Route of Administration Intravenous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Powder, Lyophilized, For Solution

About COSELA

Cosela is a medication aligned to the HCPCS J Code: J1448 for billing, pricing, and reimbursement purposes in the United States. Classified under Oncology, it is administered via the intravenous route and manufactured by Pharmacosmos.

According to CMS Drug Use Information: This medication is used to reduce the risk of blood/bone marrow problems (such as low red/white blood cells and platelets) caused by certain cancer drug treatment (chemotherapy). Trilaciclib helps to increase the number of blood cells such as red cells, white cells, and platelets. This effect may reduce the need for blood transfusions and increase your body's ability to fight an infection.

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. The list of NDCs below is not exhaustive.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
73462-0101-01	Cosela	G1 Therapeutics, Inc.	300	300 MG / 20 ML
73594-0101-01	Cosela	Pharmacosmos Therapeutics Inc.	300	300 MG / 20 ML

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COSELA Pricing & Reimbursement

J1448 Private Payer Reimbursement

$5.50 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

COSELA Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 14.45%

Avg. Days to File 10.3days

Avg. Days to Pay 27.1days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J1448 claims analytics on FocalPoint →

COSELA CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Cosela (J1448) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

COSELA Medically Unlikely Edits (MUE)

The most billing units of J1448 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

900 units / day

= 900 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

COSELA Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer (ES-SCLC) Extensive-stage small cell lung cancer (ES-SCLC)

Drug Class

Cyclin-dependent Kinase 4 Inhibitors [MoA]Cyclin-dependent Kinase 6 Inhibitors [MoA]Kinase Inhibitor [EPC]Multidrug and Toxin Extrusion Transporter 1 Inhibitors [MoA]Multidrug and Toxin Extrusion Transporter 2 K Inhibitors [MoA]Organic Cation Transporter 2 Inhibitors [MoA]

Frequently Asked Questions

Is there an available Cosela billing and coding guide?

Our team has not identified a manufacturer-published source of billing and coding information for COSELA.

Are there any available Cosela patient assistance programs?

COSELA patient assistance information can be found through G1 Therapeutics. Visit Here →

Where can I find Cosela prescribing information?

COSELA prescribing information can be found at the link below: Visit Here →

Where can I find Cosela side effect information?

Information regarding COSELA's side effects can be found at MedlinePlus Visit Here →

Does billing COSELA require JZ/JW wastage modifiers?

CMS has identified COSELA(J1448) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

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