BUSULFAN J Code: J0594

Drug & Product Overview

HCPCS Descriptor injection, busulfan, 1 mg

HCPCS Added Date January 1, 2007

Manufacturer Multiple Manufacturers

Route of Administration Intravenous

Generic Status Multi-Source; Generic

Dosage Type Single-Dose

Dosage Form Injection | Injection, Solution | Injection, Solution, Concentrate | Not Available

About BUSULFAN

Busulfan is a medication aligned to the HCPCS J Code: J0594 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the intravenous route and manufactured by multiple companies.

According to CMS Drug Use Information: Busulfan is used as a pretreatment for patients who are undergoing stem cell transplant for chronic myelogenous leukemia (CML).

Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.

NDC Code Information

Based on publicly available CMS files. Showing 5 of 10 NDCs — log in for the full crosswalk.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
00409-1112-01	Busulfan	Hospira, Inc.	480	60 MG / 10 ML
16729-0351-92	Busulfan	Accord Healthcare, Inc	480	60 MG / 10 ML
25021-0241-10	Busulfan	Sagent Pharmaceuticals	480	60 MG / 10 ML
59148-0070-91	Busulfan	Otsuka America Pharmaceuticals Inc.	480	60 MG / 10 ML
67457-0893-08	Busulfan	Mylan Institutional LLC	480	6 MG
•••••-••••-•• Log in to view	BUSULFAN
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BUSULFAN Pricing & Reimbursement

J0594 Private Payer Reimbursement

$0.94 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

Create an account on PayerPrice for more information →

Historical Graphing and Billing Calculator

per HCPCS unit

As of Q3 2026

BUSULFAN Claims Performance

Claims from Jan 2026 – Aug 2026

Claim Denial Rate 26.67%

Avg. Days to File 7.8days

Avg. Days to Pay 23.9days

Real-world claims performance from FocalPoint, OnPoint Oncology's reimbursement analytics platform, with claims data accrued at the clearing house level.

Explore J0594 claims analytics on FocalPoint →

BUSULFAN CPT Administration Codes

CPT Code	Description
96413	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415	Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)

JW / JZ modifiers apply

CMS has identified Busulfan (J0594) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. Wastage billing guide →

BUSULFAN Medically Unlikely Edits (MUE)

The most billing units of J0594 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 1 mg.

Practitioner Office & Hospital Outpatient

320 units / day

= 320 mg per day

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

BUSULFAN Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chronic Myelogenous Leukemia Chronic myelogenous leukemia

Drug Class

Alkylating Activity [MoA]Alkylating Drug [EPC]

Frequently Asked Questions

Is there an available Busulfan billing and coding guide?

We have not yet identified a manufacturer source of Busulfan billing and coding information.

Are there any available Busulfan patient assistance programs?

Our team did not identify a source for Busulfan patient assistance information. Please reach out to our team if you feel that this is a mistake.

Where can I find Busulfan prescribing information?

BUSULFAN prescribing information can be found at the link below. Please reach out to us if you believe this information to be innacurate or out of date. Visit Here →

Where can I find Busulfan side effect information?

Our team has not yet identified a source of side effects information for BUSULFAN. Please check back in a few weeks.

Does billing BUSULFAN require JZ/JW wastage modifiers?

CMS has identified BUSULFAN(J0594) as a HCPCS code with single-dose containers. Therefore, the JW/JZ wastage modifiers could be required for billing purposes. See CMS guidelines on use of the JZ and JW wastage modifiers below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.