ACTIMMUNE J Code: J9216

Self-Administered Drug Exclusion 7 Medicare Administrative Contractors list J9216 as usually self-administered and exclude it from Part B coverage in their jurisdictions. Check the article for your MAC before billing: CGS, First Coast, Noridian (A53032), Noridian (A53033), Novitas, Palmetto, Wellpoint Federal, WPS · All SAD lists →

Drug & Product Overview

HCPCS Descriptor Injection, interferon, gamma 1-b, 3 million units

HCPCS Added Date January 1, 1993

Manufacturer Amgen

Route of Administration Subcutaneous

Generic Status Single-Source; Branded

Dosage Type Single-Dose

Dosage Form Injection, Solution

About ACTIMMUNE

Actimmune is a medication aligned to the HCPCS J Code: J9216 for billing, pricing, and reimbursement purposes in the United States. This Oncology medication is administered via the subcutaneous route and manufactured by Amgen.

Manufacturers, reach out to us to add more information.

NDC Code Information

2 NDC packages are crosswalked to J9216. Package detail is available to logged-in subscribers.

NDC Code	Drug	Manufacturer	Billing Units / Pkg	Package Size
•••••-••••-•• Log in to view	ACTIMMUNE
	ACTIMMUNE

Login to view 2 NDC packages View pricing, complete NDC-to-HCPCS alignments, and package details.

ACTIMMUNE Pricing & Reimbursement

J9216 Private Payer Reimbursement

$8,732.72 / HCPCS unit as of Jan 2026

National median reimbursement across major commercial payers.

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ACTIMMUNE CPT Administration Codes

CPT Code	Description
96372	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intramuscular

Not on the CMS JW / JZ list

CMS does not include Actimmune (J9216) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9216. Wastage billing guide →

ACTIMMUNE Medically Unlikely Edits (MUE)

The most billing units of J9216 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 3 million units. The limit is different in the office and the hospital. Use the one for your setting.

Practitioner Office

2 units / day

= 6 million units per day

Hospital Outpatient

0 units / day

Not payable in this setting

MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →

ACTIMMUNE Clinical Information

Indications and drug classification.

Treated Diseases & Conditions

This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.

Chronic granulomatous disease Severe, malignant osteopetrosis

Drug Class

Interferon gamma [EPC]Interferon-gamma [CS]

Frequently Asked Questions

Is there an available Actimmune billing and coding guide?

Billing and coding information for ACTIMMUNE can be found through Horizon Therapeutics. Visit Here →

Are there any available Actimmune patient assistance programs?

ACTIMMUNE patient assistance information can be found through Horizon Therapeutics. Visit Here →

Where can I find Actimmune prescribing information?

ACTIMMUNE prescribing information can be found at the link below: Visit Here →

Where can I find Actimmune side effect information?

Information regarding ACTIMMUNE's side effects can be found at MedlinePlus Visit Here →

Does billing ACTIMMUNE require JZ/JW wastage modifiers?

CMS does not include ACTIMMUNE (J9216) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J9216. For more information, visit the link below.

About BuyandBill.com:

The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.