EPOPROSTENOL SODIUM J Code: J1325
Injection, epoprostenol, 0.5 mg
Q4 2026 Medicare Payment Limit for J1325, effective October 1, 2026: $17.247 per HCPCS billing unit, up 1.9% from $16.918. From CMS's final file.
Drug & Product Overview
About EPOPROSTENOL SODIUM
Epoprostenol Sodium is a medication aligned to the HCPCS J Code: J1325 for billing, pricing, and reimbursement purposes in the United States. Classified under Cardiology, it is administered via the intravenous route and manufactured by multiple companies.
According to CMS Drug Use Information: This medication is used to treat high blood pressure in the lungs (pulmonary arterial hypertension). It helps to increase your ability to exercise and improve symptoms such as shortness of breath and tiredness. It works by relaxing and widening the blood vessels (arteries) in the lungs and other parts of the body so that blood can flow more easily. This medication belongs to a class of drugs known as vasodilators.
Disclaimer: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional.
NDC Code Information
Based on publicly available CMS files. Showing 5 of 8 NDCs — log in for the full crosswalk.
| NDC Code | Drug | Manufacturer | Billing Units / Pkg | Package Size |
|---|---|---|---|---|
| 00173-0517-00 | Flolan | GlaxoSmithKline LLC | 1 | 0.5 MG |
| 00173-0519-00 | Flolan | GlaxoSmithKline LLC | 3 | 1.5 MG |
| 62756-0059-40 | epoprostenol | Sun Pharmaceutical Industries, Inc. | 1 | 0.5 MG / 10 ML |
| 66215-0402-01 | Veletri | Actelion Pharmaceuticals US, Inc. | 3 | 1.5 MG / 10 ML |
| 67457-0587-10 | Epoprostenol | Mylan Institutional LLC | 1 | 0.5 MG / 10 ML |
| •••••-••••-•• Log in to view | EPOPROSTENOL SODIUM | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | EPOPROSTENOL SODIUM | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
| •••••-••••-•• Log in to view | EPOPROSTENOL SODIUM | •••••••••••• Log in to view | •••• Log in to view | ••• •• / • •• Log in to view |
EPOPROSTENOL SODIUM Pricing & Reimbursement
National median reimbursement across major commercial payers.
Create an account on PayerPrice for more information →
Historical Graphing and Billing Calculator
Log in to calculate billing and reimbursement with live ASP, WAC & AWP pricing.
Login to use the calculator →EPOPROSTENOL SODIUM CPT Administration Codes
The below list of CPT codes is intended for informational purposes only and may not be exhaustive. CPT® codes and descriptions are copyright American Medical Association (AMA). All rights reserved.
| CPT Code | Description |
|---|---|
| 96365 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour |
| 96366 | Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure) |
CMS does not include Epoprostenol Sodium (J1325) on its list of HCPCS pertaining to single-dose containers. Per CMS guidelines, the JZ/JW wastage modifiers may not apply when billing J1325. Wastage billing guide →
EPOPROSTENOL SODIUM Medically Unlikely Edits (MUE)
The most billing units of J1325 Medicare will pay for one patient in one day, as published by CMS. 1 unit = 0.5 mg. The limit is different in the office and the hospital. Use the one for your setting.
MAI 3 · Date of Service Edit: Clinical. Per-day limit based on clinical expectations; excess units are denied but may be appealed with documentation of medical necessity. See all MUE limits →
EPOPROSTENOL SODIUM Clinical Information
Indications and drug classification.
This list of indications is not exhaustive and may be subject to errors. The information on BuyandBill.com is intended for informational purposes only and should not be used for medical advice.
Login for BuyandBill.com Analytics
Unlock deeper insights with BuyandBill’s Comparative Report!
- Compare ASP, WAC, and AWP across drugs.
- Visualize Drug Price Movement Over Time
- Tailor reports to drug class, manufacturer, or HCPCS Code.
- Compare Biosimilar and 505(b)(2) products.
Frequently Asked Questions
Is there an available Epoprostenol Sodium billing and coding guide?
Are there any available Epoprostenol Sodium patient assistance programs?
Where can I find Epoprostenol Sodium prescribing information?
Where can I find Epoprostenol Sodium side effect information?
Does billing EPOPROSTENOL SODIUM require JZ/JW wastage modifiers?
About BuyandBill.com:
The BuyandBill.com team is dedicated to delivering high-quality coding and billing information for office-administered drugs. We continuously research HCPCS-coded medications to expand our resources and ensure data accuracy. Manufacturers: click here to sponsor your medication, and we will ensure the most accurate and detailed information is displayed.
Related Drug Codes
Explore billing, coding, and pricing for drugs related to EPOPROSTENOL SODIUM.
