All Biosimilar Drugs and their Reference Products

A biosimilar is a biological product that is highly similar to an existing FDA-approved reference product. Biosimilars are not generic versions of brand-name drugs; instead, they are comparable but not identical versions of original “innovator” biologic drugs. Generic drugs are identical to a brand-name drug in dosage form, safety, strength, route of administration, quality, performance characteristics, and intended use. Biosimilars, though highly similar to the reference product, are not exact copies.

Q codes are a type of HCPCS code used in the healthcare industry to identify services and items for Medicare beneficiaries. Codes that begin with Q5 specifically pertain to biosimilar drugs. For example, Q5118 is the Q code for the biosimilar Zirabev, a biosimilar of the cancer drug Avastin.

Below, are all biosimilar drugs and their HCPCS codes, mapped to their reference products:

Biosimilar DrugBiosimilar HCPCSReference DrugReference HCPCS
VEGZELMAQ5129AVASTINJ9035
ZIRABEVQ5118AVASTINJ9035
MVASIQ5107AVASTINJ9035
ALYMSYSQ5126AVASTINJ9035
RETACRITQ5106EPOGEN/PROCRITJ0885
RETACRITQ5105EPOGEN/PROCRITJ0885
KANJINTIQ5117HERCEPTINJ9355
TRAZIMERAQ5116HERCEPTINJ9355
OGIVRIQ5114HERCEPTINJ9355
HERZUMAQ5113HERCEPTINJ9355
ONTRUZANTQ5112HERCEPTINJ9355
BYOOVIZQ5124LUCENTISJ2778
NYVEPRIAQ5122NEULASTAJ2506
ZIEXTENZOQ5120NEULASTAJ2506
UDENYCAQ5111NEULASTAJ2506
FULPHILAQ5108NEULASTAJ2506
FYLNETRAQ5130NEULASTAJ2506
STIMUFENDQ5127NEULASTAJ2506
ZARXIOQ5101NEUPOGENJ1442
RELUKOQ5125NEUPOGENJ1442
NIVESTYMQ5110NEUPOGENJ1442
AVSOLAQ5121REMICADEJ1745
RENFLEXISQ5104REMICADEJ1745
INFLECTRAQ5103REMICADEJ1745
RUXIENCEQ5119RITUXANJ9312
TRUXIMAQ5115RITUXANJ9312
RIABNIQ5123RITUXANJ9312